白血病的抗血管生成治疗策略被引量：1

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摘要白血病的发生、发展和预后与骨髓血管生长程度及血管生成调控因子高表达密切相关。因此抑制内皮细胞增殖、封闭刺激因子受体以及阻断VEGF相关基因的表达等抗血管治疗策略有可能成为白血病治疗中的一个新靶点。

作者张伶冯文莉涂植光

出处《国外医学（临床生物化学与检验学分册）》 2002年第6期323-325,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine

基金重庆市卫生局青年人才科研资助项目编号 0 0 30 0 3

关键词白血病血管生成血管内皮细胞生长因子抗血管生成治疗

分类号 R733.7 [医药卫生—肿瘤]

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参考文献16

1Aguayo A;Kantarjian H;Manshouri T.Angiogenesis in acute and chronic leukemia and myelodysplastic syndrome,2000(06).
2Chen H;Treweeke AT;West DC.In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells,2000(09).
3Fiedler W;Graeven U;Ergun S.Vascular endothelial growth factor,a possible paracrine growth factor in human acute myeloid leukemia[J],1997(06).
4Bellamy WT;Richter L;Sirjani D.Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndrome[J],2001(05).
5Verstovsek S;Kantarjian H;Aguayo A.Significance of angiogenin plasma concentrations in patients with acute myeloid leukaemia and advanced myelodysplastic syndrome,2001(02).
6Aguayo A;Manshouri T;O'Brien S.Clinical relevance of Fltl and Tiel angiogenesis receptors expression in B-cell chronic lymphocytic leukemia (CLL),2001(04).
7Podar K;Tai YT;Davies FE.Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration[J],2001(02).
8Dias S;Choy M;Alitalo K.Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 ( VEGFR-3) mediates leukemic cells proliferation,survival,and resistance to chemotherapy[J],2002(06).
9Scappaticci FA;Smith R;Pathak A.Combination angiostatin an endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice[J],2001(02).
10Roboz GJ;Dias S;Lam G.Arsenic trioxide induces dose-and time-dependent apoptosis of endothelium and may exert and antileukemic effect via inhibition of endothelium and may exert and antileukemic effect via inhibition of angiogenesis,2000(04).

共引文献7

1魏立,孔佩艳,张怡,刘红,王庆余,陈幸华.反应停治疗恶性浆细胞疾病时的罕见不良反应[J].西部医学,2003,1(4):339-340. 被引量：1
2侯芸华,宋振岚,张永利,刘璟瑶.沙利度胺治疗急性白血病的部分机制研究[J].中国医药,2006,1(4):206-208. 被引量：7
3陆进,苗忠,查庆桂,周广政,吴天勤.沙利度胺联合化疗治疗难治性多发性骨髓瘤临床观察[J].中国医药,2006,1(4):209-211. 被引量：3
4宋修怡.多发性骨髓瘤的自体造血干细胞移植治疗[J].内科理论与实践,2010,5(1):88-92. 被引量：3
5黄杨卿,聂云天,王杰军.反应停的新生——抗肿瘤[J].国外医学（肿瘤学分册）,2001,28(1):33-35. 被引量：13
6蔡宇,王椿.沙利度胺在治疗多发性骨髓瘤中的应用[J].世界临床药物,2003,24(6):351-356. 被引量：1
7王肇炎,王尔兵.沙利度胺:一种抗血管生成的抗癌药[J].世界临床药物,2003,24(12):757-760. 被引量：4

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1李锋,陈朴,邹善华.慢性髓细胞性白血病与血管生成因子关系[J].中国癌症杂志,2004,14(5):462-465. 被引量：4
2徐喜慧,贺其图,贾国荣,宋芳,赵晓华,徐军.白血病患者骨髓血管新生的研究[J].白血病．淋巴瘤,2005,14(2):80-82. 被引量：9
3贺其图,赵晓华,贾国荣,马宏杰,李静,李喆,刘学文,云雁.白血病患者骨髓血管新生与Bcl-2蛋白关系的研究[J].实用癌症杂志,2006,21(4):376-378. 被引量：9
4唐琼兰,刘卫平,张文燕,杨帆,何妙侠,夏庆杰,李甘地.CYR61和血管内皮生长因子在结外鼻型NK/T细胞淋巴瘤中的表达及其意义[J].中华血液学杂志,2006,27(10):661-665. 被引量：24
5刘学文,贺其图.COX-2与白血病血管新生的研究[J].医学综述,2007,13(5):330-332. 被引量：1
6Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor[J]. FEBS Lett, 1993,327 (2) : 125-130.
7Planque N,Perbal B. A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis[J]. Cancer Cell International,2003,22(3) : 1-15.
8Perbal B. NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues[J]. Mol Pathol,2001,54(2) :57-79.
9Xie D, Nakachi K, Wang H, et al. Elevated levels of ccnl, ccn2 and ccn4 in primary breast cancers associated with more advanced fealures[J]. Cancer Res,2001,61 (8) :8917-8923.
10Lin MT,Chang CC,Chen ST, et al. Cyr61 Expression Confers Resistance to Apoptosis in Breast Cancer MCF-7cells by a Mechanism of NF-{kappa} B-dependent XIAP Up-Regulation [J]. Biol Chem,2004,279(23):24015-24023.