摘要
纳秒脉冲电场(Nanosecond Pused Electric Field,nsPEF)作为一种新型的实体肿瘤消融物理因子,在肝癌治疗中受到广泛关注,目前已进展到临床研究阶段。大量研究表明,nsPEF不仅能够诱导肝癌细胞凋亡、消融肝脏肿瘤,还能激发机体的先天和适应性免疫反应,抑制肝脏肿瘤的复发和转移。本文对nsPEF在肝脏肿瘤消融中的研究进展进行综述,并对尚需研究和探讨的问题进行展望,以期进一步推动nsPEF肝脏肿瘤消融的应用。
Nanosecond pulsed electric field(nsPEF),as a novel physical means for solid tumor ablation,has received widespread attention in liver cancer treatment.Currently,it’s at the clinical research stage.Extensive studies have shown that nsPEF can not only induces apoptosis of liver cancer cells and ablate liver tumors,but also stimulates the innate and adaptive immune response,and inhibits the recurrence and metastasis of liver tumors.This article reviews the research progress of nsPEF in liver tumor ablation,and provides an outlook on the issues that still need to be addressed and explored.The aim is to further promote the application of nsPEF in liver tumor ablation.
作者
杜梦茹
马若男
季振宇
华浅近
陈新华
庄杰
DU Mengru;MA Ruonan;JI Zhenyu;HUA Qianjin;CHEN Xinhua;ZHUANG Jie(Division of Life Sciences and Medicine,School of Biomedical Engineering(Suzhou),University of Sciences and Technology of China,Suzhou Jiangsu 215163,China;Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Science,Suzhou Jiangsu 215163,China;Henan Key Laboratory of Ion-beam Bioengineering,School of Agricultural Sciences,Zhengzhou University,Zhengzhou Henan 450001,China;Department of Medical Electronic Engineering,School of Biomedical Engineering,Air Force Medical University,Xi’an Shaanxi 710032,China;Department of Interventional Oncology,Taizhou Municipal Hospital,Taizhou Zhejiang 318000,China;Division of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou Zhejiang 310003,China;Zhejiang Provincial Key Laboratory of Pulsed Power Translational Medicine,Hangzhou Zhejiang 311100,China)
出处
《中国医疗设备》
2023年第5期49-55,共7页
China Medical Devices
基金
浙江省卫生科技计划(2022KY1387)
浙江省中医药科学研究基金项目(2022ZB394)
中科院百人计划(Y722171202)。
关键词
纳秒脉冲电场
肝脏肿瘤
不可逆电穿孔
非热肿瘤消融
nanosecond pulsed electric field
liver tumor
irreversible electroporation
non-thermal tumor ablation
作者简介
通信作者:庄杰,研究员,主要研究方向为电穿孔、等离子体医学、生物电磁、生物介电谱、脉冲功率技术.邮箱:jzhuang@sibet.ac.cn.
