摘要
目的 分析2019—2021年上海市金山区企业人群麻疹风疹联合减毒活疫苗(measles and rubella combined attenuated live vaccine,MR)补充免疫(supplementary immunization activity,SIA)的效果。方法 收集2019—2021年金山区437名企业人员MR疫苗接种前和接种后1个月血清,2 mL/人,ELISA法定量检测麻疹IgG抗体水平,计算几何平均浓度(geometric mean concentration,GMC)。麻疹IgG抗体GMC≥200 mIU/mL时判为抗体阳性,≥800 mIU/mL为保护性抗体阳性;接种MR后,麻疹IgG抗体由阴性转为阳性或麻疹IgG水平升高≥4倍时,判为免疫有效。结果MR接种前麻疹抗体阳性率、保护性抗体阳性率和IgG抗体GMC分别为90.85%、38.44%、795.29 mIU/mL,接种后分别为99.31%、76.20%、1 481.51 mIU/mL。免疫后保护性抗体阳性率(χ^(2)=21.290,P <0.001)和IgG抗体GMC均明显高于免疫前(t=19.548,P <0.001)。免疫有效率为26.54%,且随着免疫前抗体水平升高呈递减趋势(χ^(2)=119.022,P <0.001)。结论 在低麻疹抗体水平人群中开展MR SIA效果良好,建议在企业低麻疹抗体水平人员中进行含麻疹成分疫苗的SIA。
Objective To determine the effect of measles and rubella combined attenuated live vaccine(MR)supplementary immunization activities(SIA)of enterprise employees in Jinshan District,Shanghai from 2019 to 2021.Methods A total of 437 enterprise employees immunized with MR were collected for the serum samples of 2 ml before and one month after immunization in Jinshan District from 2019 to 2021.The IgG level against measles was determined by ELISA,and the geometric mean concentration(GMC)was calculated.The antibody against measles was judged as positive when the GMC of IgG antibody was more than 200 mIU/mL,while the protective antibody was positive when the GMC was more than800 mIU/mL;After MR vaccination,the immunity was judged to be effective when measles IgG antibody changed from negative to positive or IgG level against measles increased more than 4 times.ResultsThe antibody positive rate,positive rate of protective antibody and IgG antibody GMC of measles before MR vaccination were 90.85%,38.44% and795.29 mIU/mL,while 99.31%,76.20% and 1 481.51 mIU/mL after vaccination,respectively.The positive rate of protective antibody(χ^(2)= 21.290,P<0.001)and the GMC of IgG antibody after immunization were significantly higher than those before immunization(t = 19.548,P<0.001).The vaccination success rate was 26.54%,which decreased with the increase of antibody level before vaccination(χ^(2)= 119.022,P<0.001).ConclusionThe effect of MR SIA in the population with low measles antibody level was good,which suggested that SIA of measles-containing vaccine should be carried out in enterprise employees with low level of measles antibody.
作者
周杰
施娟辉
王芳
李淑华
ZHOU Jie;SHI Juanhui;WANG Fang;LI Shuhua(Jinshan District Center for Disease Control and Prevention,Shanghai 201599,China;不详)
出处
《中国生物制品学杂志》
CAS
CSCD
北大核心
2023年第4期448-451,457,共5页
Chinese Journal of Biologicals
基金
上海市卫生计生委立项课题(201740074)
上海市自然科学基金立项课题(17ZR1424500)。
关键词
麻疹风疹联合减毒活疫苗
抗体
酶联免疫吸附试验
补充免疫
Measles and rubella combined attenuated live vaccine(MR)
Antibodies
Enzyme linked immunosorbent assay
Supplementary immunization activity(SIA)
作者简介
通信作者:李淑华,E-mail:hsli167@163.com。
