摘要
非编码RNA(ncRNA)是指不编码蛋白质但具有重要功能的RNA。转运RNA的衍生片段(tRF)是一类新兴的ncRNA,越来越多的研究发现它在许多方面发挥着重要作用,而不是简单的降解产物。比如,tRF可以控制基因表达水平,调节转录和翻译;且tRF与细胞的自我更新、增殖、分化密切相关。因此,tRF可能会导致多种疾病,如癌症、神经退行性疾病、免疫系统紊乱等。该文则主要介绍tRF的分类、主要生物学功能以及分子学生物和生物信息学研究方法。
ncRNA(noncoding RNA)is a kind of RNA that does not encode protein but has important function.tRF is a new type of ncRNA.More and more studies have found that it plays important roles in many aspects,rather than a simple degradation product.For example,tRF can control gene expression,regulate transcription and translation,and it is closely related to cell self-renewal,proliferation and differentiation.Therefore,tRF may be involved in a variety of diseases,such as cancer,neurodegenerative diseases,immune system disorders and so on.This paper mainly introduces the classification,main biological functions and research methods of biomolecules and bioinformatics of tRF.
作者
曹玥
杨慧
王晚璞
CAO Yue;YANG Hui;WANG Wanpu(Medical College,Kunming University of Science and Technology,Kunming 650500,China;Department of Pathology,Affiliated Hospital of Kunming University of Science and Technology/Yunnan First People’s Hospital,Kunming 650032,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2023年第3期491-501,共11页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81660238)
云南省基础研究计划(批准号:202101AT070238)
云省医学学科后备人才项目(批准号:H2019001)
云南省临床医学中心开放项目(批准号:2020LCZXKF-XY13)资助的课题。
作者简介
通讯作者:王晚璞。Tel:13888417808,E-mail:828986@qq.com。
