摘要
目的:探讨无抽搐电休克联合喹硫平在双相情感障碍(BD)躁狂发作患者中的效果。方法:采用随机数字表法将2020年6月-2022年6月上饶市第三人民医院收治的60例BD躁狂发作患者分为对照组(30例,接受喹硫平治疗)和研究组(30例,在喹硫平治疗基础上加用无抽搐电休史治疗)。比较两组精神状况、治疗效果、氧化应激水平和认知功能。结果:两组治疗前精神状况、氧化应激水平和认知功能比较,差异均无统计学意义(P>0.05);治疗后,研究组简明Bech-Rafaelsen躁狂量表(BRMS)评分为(6.35±2.08)分,低于对照组的(17.92±3.18)分,差异有统计学意义(P<0.05)。研究组治疗总有效率为96.67%(29/30),高于对照组的80.00%(24/30),差异有统计学意义(P<0.05)。研究组治疗后超氧化物歧化酶(SOD)为(132.28±13.05)U/mL,谷胱甘肽过氧化物酶(GSH-Px)为(153.53±12.64)U/L,过氧化氢酶(CAT)为(1.86±0.52)U/mL,均高于对照组的(119.98±12.76)U/mL、(145.02±12.18)U/L、(1.40±0.51)U/mL;丙二醛(MDA)为(3.02±0.69)nmol/mL,低于对照组的(4.69±1.02)nmol/mL,差异均有统计学意义(P<0.05)。研究组治疗后持续操作测验(CPT)为(0.69±0.13)分,威斯康星卡片分类测验(WCST)为(49.79±3.42)分,言语记忆测验(HVLT-R)为(25.59±3.14)分,均高于对照组的(0.53±0.11)、(46.98±3.38)、(23.67±3.02)分,差异均有统计学意义(P<0.05)。结论:无抽搐电休克联合喹硫平较单纯喹硫平治疗BD躁狂发作效果更好,能够缓解患者精神症状,改善患者氧化应激水平,提升患者认知功能水平,值得临床推广。
Objective:To investigate the effect of non convulsive electroconvulsive shock therapy combined with Quetiapine in manic episode patients with bipolar disorder(BD).Method:A total of 60 patients with manic episode of BD admitted to Shangrao Third People's Hospital from June 2020 to June 2022 were divided into the control group(30 patients,treated with Quetiapine)and the study group(30 patients,treated with non convulsive electroconvulsive shock on the basis of Quetiapine)by random number table method.The mental status,therapeutic effect,oxidative stress level and cognitive function of the two groups were compared.Result:There were no significant differences in mental status,oxidative stress level and cognitive function between the two groups before treatment(P>0.05);the BRMS score of the study group after treatment was(6.35±2.08)points,which was lower than(17.92±3.18)points of the control group,the difference was statistically significant(P<0.05).The total effective rate of treatment in the study group was 96.67%(29/30),which was higher than 80.00%(24/30)in the control group,the difference was statistically significant(P<0.05).The superoxide dismutase(SOD)was(132.28±13.05)U/mL,glutathione peroxidase(GSH-Px)was(153.53±12.64)U/L,catalase(CAT)was(1.86±0.52)U/mL in the study group after treatment,which they were higher than(119.98±12.76)U/mL,(145.02±12.18)U/L,(1.40±0.51)U/mL of the control group,the level of malondialdehyde(MDA)was(3.02±0.69)nmol/mL in the study group,which was lower than(4.69±1.02)nmol/mL in the control group,the differences were statistically significant(P<0.05).After treatment,the scores of CPT,WCST and HVLT-R in the study group were(0.69±0.13),(49.79±3.42)and(25.59±3.14)points respectively,which were higher than(0.53±0.11),(46.98±3.38),(23.67±3.02)points in the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of modified electroconvulsive therapy combined with Quetiapine is better than that of Quetiapine alone in the treatment of manic episode of BD,which can alleviate the mental symptoms of patients,improve the level of oxidative stress and enhance the cognitive function of patients,and is worthy of clinical promotion.
作者
方钱禹
吴艳
程良红
FANG Qianyu;WU Yan;CHENG Lianghong(Shangrao Third People's Hospital,Jiangxi Province,Shangrao 334000,China;不详)
出处
《中国医学创新》
CAS
2023年第12期47-51,共5页
Medical Innovation of China
基金
江西省卫生健康委科技计划项目(202212787)。
关键词
双相情感障碍躁狂发作
无抽搐电休克
喹硫平
氧化应激水平
认知功能
Manic episode of bipolar disorder
Non convulsive electroconvulsive shock
Quetiapine
Oxidative stress level
Cognitive function
作者简介
通信作者:方钱禹。
