摘要
小细胞外囊泡(small extracellular vesicles,sEVs)是近几年纳米医学界的新星,它有着独特的形态结构和理化性质,可以充当细胞间信息传递的介质,并作为疾病发生发展过程中的生物学标志物。现今人们越来越关注皮肤光老化问题,有关sEVs延缓和改善皮肤光老化的研究也逐渐成为热点。来源于间充质干细胞的sEVs不仅在皮肤光老化中有减轻炎症反应和减弱氧化损伤等的作用,而且对于其他皮肤疾病(例如皮肤创伤、斑块状银屑病、系统性红斑狼疮以及皮肤肿瘤等)也有着显著的作用。此外,由于sEVs的囊泡性质,sEVs正在成为一种新的药物递送系统。然而在将干细胞源性sEVs作为一种新的治疗方法时,仍需重视其安全性和毒性问题。
sEVs(small extracellular vesicles)are new stars in the field of nanomedicine in recent years.They have unique morphological structures and physicochemical properties,which can act as mediators of intercellular information transmission and as biomarkers in the process of disease occurrence and development.Nowadays,people are paying more and more attention to the problem of skin photoaging,and the research on sEVs delaying and improving skin photoaging has gradually become a hot spot.sEVs derived from mesenchymal stem cells not only relieve inflammation and attenuate oxidative damage in skin photoaging,but also have significant effects on other skin diseases,such as skin trauma,plaque psoriasis,systemic erythema lupus and skin tumors.Furthermore,sEV is becoming a new drug delivery system due to its vesicular nature.However,when using stem cell-derived sEV as a new treatment method,it is still necessary to pay attention to its safety and toxicity.
作者
孔翔
徐开颜
吴芷菁
吴佩佩
侯小美
张佳昕
李钰
李加利
孙梓暄
KONG Xiang;XU Kaiyan;WU Zhijing;WU Peipei;HOU Xiaomei;ZHANG Jiaxin;LI Yu;LI Jiali;SUN Zixuan(School of Medicine,Jiangsu University,Zhenjiang 212013,China;Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application,Zhenjiang 212013,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2023年第2期334-344,共11页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:82003379)
江苏大学大学生创新创业训练计划(批准号:2021102991071X)资助的课题。
作者简介
共同第一作者:孔翔;共同第一作者:徐开颜;共同第一作者:吴芷菁;通信作者:孙梓暄,Tel:15189188992,E-mail:zxsun321@126.com。
