摘要
Mesenchymal stem cells(MSCs)are self-renewing,multipotent cells that could differentiate into multiple tissues.MSC-based therapy has become an attractive and promising strategy for treating human diseases through immune regulation and tissue repair.However,accumulating data have indicated that MSC-based therapeutic effects are mainly attributed to the properties of the MSC-sourced secretome,especially small extracellular vesicles(sEVs).sEVs are signaling vehicles in intercellular communication in normal or pathological conditions.sEVs contain natural contents,such as proteins,mRNA,and microRNAs,and transfer these functional contents to adjacent cells or distant cells through the circulatory system.MSC-sEVs have drawn much attention as attractive agents for treating multiple diseases.The properties of MSC-sEVs include stability in circulation,good biocompatibility,and low toxicity and immunogenicity.Moreover,emerging evidence has shown that MSC-sEVs have equal or even better treatment efficacies than MSCs in many kinds of disease.This review summarizes the current research efforts on the use of MSC-sEVs in the treatment of human diseases and the existing challenges in their application from lab to clinical practice that need to be considered.
基金
Supported by National Natural Science Foundation of China,No.81971878
Opening Project of Military Logistics,No.BLB19J006
and Tianjin University Independent Innovation Fund,No.2020XRG-0027,No.2020XYF-0041,and No.2020XZY-0086.
作者简介
Corresponding author:Qi Lv,MD,PhD,Academic Research,Associate Professor,Institute of Disaster Medicine,Tianjin University,No.92 Weijin Road,Nankai District,Tianjin 300072,China.lvqi68@163.com,Qi Lv 0000-0001-9076-7042;ORCID number:Jie Shi 0000-0001-8921-9559;Yu-Chen Zhao 0000-0002-4800-0144;Zhi-Fang Niu 0000-0003-2123-6912;Hao-Jun Fan 0000-0003-1111-0232;Shi-Ke Hou 0000-0001-6097-0867;Xiao-Qin Guo 0000-0003-1647-4385;Lu Sang 0000-0002-1703-5344。
