摘要
目的 探讨血小板相关参数与早产儿动脉导管未闭(patent ductus arteriosus,PDA)的关系。方法 选取我院收治的54例早产PDA患儿设为观察组;另外选择同期于我院分娩无PDA的54例早产儿设为对照组。分别收集两组早产儿及产妇的基础资料信息(胎龄、性别、出生体重、Apgar评分、住院时间及年龄、产次、分娩方式、有无妊娠期高血压、有无妊娠期糖尿病、产前是否使用硫酸镁),另外于两组早产儿出生后3 d(首次)及超声确诊PDA当日(第2次)取桡动脉血2 mL,检测血小板计数(platelet count,PLT)、平均血小板体积(mean platelet volume,MPV)、血小板压积(platelet hematocrit,PCT)、血小板分布宽度(platelet distribution width,PDW),最后通过ROC分析PLT、MPV、PCT预测早产儿出现PDA的价值。结果 两组产妇年龄、产次、分娩方式、合并妊娠期高血压、合并糖尿病、早产儿性别、Apgar评分、住院时间、首次及第2次测量PDW水平比较差异无统计学意义(P>0.05);观察组产妇产前使用硫酸镁占比显著高于对照组,观察组早产儿胎龄、出生体重以及首次及第2次测量PLT、MPV、PCT显著低于对照组(P<0.05)。经ROC分析证实PLT、MPV、PCT均能用于早产儿出现PDA的预测,曲线下面积分别为0.802、0.806、0.859,P<0.05。结论 相对于无PDA早产儿,PDA早产儿体内血小板参数存在明显异常,经ROC分析证实PLT<195.805×10^(9)/L、MPV<10.600 fL、PCT<0.225%能够用于早产儿出现PDA的预测,临床医师应当予以关注。
Objective To explore the relationship between platelet-related parameters and patent ductus arteriosus(PDA)in premature infants.Methods A total of 54 children with preterm PDA admitted to our hospital were selected as the research subjects and set as the observation group.In addition,54 premature infants who were delivered in our hospital during the same period without PDA were selected as control group.The basic information of premature infant and puerperants(gestational age,sex,birth weight,and Apgar score,hospitalization days,maternal age,number of births,mode of delivery,presence or absence of gestational hypertension,presence or absence of gestational diabetes,and prenatal use of magnesium sulfate)were collected in the two groups.In addition,2 mL of radial artery blood was taken from both groups of premature infants at three days after birth(the first time)and on the day of diagnosis of PDA by ultrasound(the second time).Platelet count(PLT),mean platelet volume(MPV),platelet hematocrit(PCT),and platelet distribution width(PDW)were detected.Finally,receiver operating characteristic(ROC)curve was used to analyze the value of PLT,MPV and PCT in predicting the occurrence of PDA in premature infants.Results There was no significant difference between two groups in terms of maternal age,number of births,mode of delivery,hypertension complicating pregnancy,complicated diabetes,sex of premature infants,Apgar score,days of hospitalization,PDW level measured for the first time and the second time(P>0.05).The proportion of pregnant women in the observation group using magnesium sulfate before delivery was significantly higher than that in the control group,while the gestational age,birth weight,as well as PLT,MPV,and PCT of premature infants measured for the two times in the observation group were significantly lower than those in the control group(P<0.05).ROC analysis confirmed that PLT,MPV and PCT could all be used to predict the occurrence of PDA in premature infants.The area under the ROC curve was 0.802,0.806 and 0.859,respectively(all P<0.05).Conclusion Compared with preterm infants without PDA,the platelet parameters in preterm PDA infants was significantly abnormal.The ROC analysis has confirmed that PLT<195.805×10^(9)/L,MPV<10.600 fL and PCT<0.225%can be used to predict the occurrence of PDA in preterm infants,which warrants the attention of clinicians.
作者
朱宝莉
江敏
姜善雨
ZHU Bao-li;JIANG Min;JIANG Shan-yu(Department of Neonatal Pediatrics,Wuxi Maternal and Child Health Hospital,Jiangsu Province,Wuxi 214000,China)
出处
《河北医科大学学报》
CAS
2023年第4期450-453,464,共5页
Journal of Hebei Medical University
作者简介
朱宝莉(1985-),女,江苏无锡人,江苏省无锡市妇幼保健院主治医师,医学学士,从事新生儿疾病诊治研究;通信作者:江敏。E-mail:13585004819@163.com。
