摘要
目的探讨硫酸镁联合拉贝洛尔对妊高征(PIH)患者血压控制及妊娠结局的影响.方法选取2019年9月—2021年8月我院收治的80例PIH患者,按随机数字表法分为两组,每组40例.对照组采用硫酸镁治疗,观察组采用硫酸镁联合拉贝洛尔治疗,均治疗2周并观察至患者分娩.比较两组的临床疗效、血压水平、炎症指标、妊娠结局及不良反应发生情况.结果观察组的治疗总有效率为97.50%,高于对照组的77.50%,差异有统计学意义(P<0.05).治疗前,两组的血压水平、炎症指标水平比较,组间差异无统计学意义(P>0.05);治疗2周后,观察组的收缩压、舒张压、超敏C反应蛋白分别为(125.44±4.83)mmHg、(75.30±4.98)mmHg、(3.29±0.47)mg/L,均低于对照组,组间差异有统计学意义(P<0.05).观察组的不良妊娠结局发生率为5.00%,低于对照组的20.00%,差异有统计学意义(P<0.05).两组均无严重不良反应发生.结论硫酸镁联合拉贝洛尔能提高PIH的临床疗效,稳定控制血压水平,改善妊娠结局,安全可靠.
Objective To investigate the effect of magnesium sulfate combined with labetalol on blood pressure control and pregnancy outcome in patients with pregnancy induced hypertension(PIH).Methods A total of 80 patients with PIH admitted to our hospital from September 2019 to August 2021 were selected and divided into two groups according to random number table method,with 40 patients in each group.The control group was treated with magnesium sulfate,and the observation group was treated with magnesium sulfate combined with labetalol.Both groups were treated for 2 weeks and observed till delivery.The clinical efficacy,blood pressure level,inflammatory index,pregnancy outcome and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.50%,which was higher than 77.50%of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in blood pressure and inflammatory marker levels between the two groups(P>0.05);after 2 weeks of treatment,the systolic blood pressure,diastolic blood pressure and hypersensitive C-reactive protein in the observation group were(125.44±4.83)mmHg,(75.30±4.98)mmHg and(3.29±0.47)mg/L,respectively,lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 5.00%,lower than 20.00%in the control group,and the difference was statistically significant(P<0.05).No serious adverse reactions occurred in both groups.Conclusion Magnesium sulfate combined with labetalol can improve the clinical efficacy of PIH,control blood pressure level stably,improve pregnancy outcome,safe and reliable.
作者
胡素真
HU Suzhen(Department of Obstetrics and Gynecology,Jinxiang County People's Hospital,Jining Shandong,272200,China)
出处
《反射疗法与康复医学》
2022年第11期158-160,共3页
Reflexology And Rehabilitation Medicine
关键词
妊高征
硫酸镁
拉贝洛尔
临床疗效
血压水平
妊娠结局
不良反应
Pregnancy induced hypertension
Magnesium sulphate
Labetalol
Clinical efficacy
Blood pressure level
Pregnancy outcome
Adverse reactions
作者简介
胡素真(1982-),女,山东济宁人,本科,主治医师,研究方向:妇产科临床。
