摘要
透明质酸(hyaluronic acid,HA)具有良好的理化性质和优越的生物活性,是制备水凝胶涂层理想的生物材料。对天然HA进行物理或化学改性后的HA水凝胶已逐渐应用于医用导管表面功能改性的领域,例如制备润滑、抗炎、改善血液相容性和生物医学防污的涂层。但应用于医用导管表面的HA水凝胶的涂层技术仍存在未被攻克的难题,尤其是涂层的粘附性与稳定性,涂层中适宜的HA含量以及涂层成分配比等。该研究分析了HA涂层技术难题的影响因素并提出了改进建议。
Hyaluronic acid(HA)has favorable physicochemical properties and superior biological activities,which is an ideal biomaterial for preparing hydrogel coating.After physically or chemically modifying,HA-based hydrogel coating has been gradually applied to functional modification for medical catheters surface,such as hydrophilic lubricating coating,anti-inflammatory coating,biomedical antifouling coating and blood compatibility improved coating.However,there are still intractable problems in the coating technology of HA hydrogel which is applied to the surface of medical catheters,especially in adhesion,stability and element proportion of HA coating.Finally,the related influencing factors and improvement suggestions are analyzed in this study.
作者
廖曦
刘雨薇
冯金华
李卡
LIAO Xi;LIU Yuwei;FENG Jinhua;LI Ka(Department of Colorectal Cancer,West China Hospital,Sichuan University,Chengdu,610041;West China School of Nursing,Sichuan University,Chengdu,610041)
出处
《中国医疗器械杂志》
2023年第2期173-177,共5页
Chinese Journal of Medical Instrumentation
基金
国家重点研发计划课题(2018YFC2001805)
四川省科技计划项目-重点研发项目(2021YFS0022)
四川大学华西医院学科卓越发展135工程项目-交叉学科创新项目(ZYJC21057)。
关键词
透明质酸
医用导管
功能改性
水凝胶
涂层
hyaluronic acid
medical catheter
functional modification
hydrogel
coating
作者简介
廖曦,E-mail:2379133447@qq.com;通信作者:李卡,E-mail:Likalika127127@163.com。
