摘要
目的 探究ASO患者血管介入术后ET-1、sTREM-1、VEGF水平联合检测对血管再狭窄发生的预测价值。为ASO患者血管介入术后血管再狭窄发生的诊治提供参考。方法 选择2018年1月1日-2020年10月1日某院收治的103例下肢ASO患者,均行血管介入术,根据其术后1年是否发生血管再狭窄分为未发生组(n=72)与发生组(n=31),比较两组基本情况及血清ET-1、sTREM-1、VEGF水平,用Logistic回归模型进行下肢ASO患者血管介入术后血管再狭窄的单因素和多因素分析,用受试者工作特征曲线(ROC)分析血清ET-1、sTREM-1、VEGF预测下肢ASO患者血管介入术后血管再狭窄的价值。结果 发生组ET-1、sTREM-1、VEGF水平显著高于未发生组(P<0.05)。单因素Logistic回归分析显示,血尿酸(SUA)、纤维蛋白原(FIB)、低密度脂蛋白胆固醇(LDL-C)、ET-1、sTREM-1、VEGF水平与血管再狭窄发生相关(P<0.05),进一步多因素Logistic回归分析显示,ET-1、sTREM-1、VEGF高水平是血管再狭窄发生的危险因素(P<0.05)。ROC曲线显示,当ET-1、sTREM-1、VEGF最佳界值依次为328.66 pg/mL、179.89 ng/L、72.80 pg/mL时,其联合预测的AUC为0.897,敏感性为90.31、特异性为76.40。结论 下肢ASO患者血管介入术后血清ET-1、sTREM-1、VEGF水平联合检测对血管再狭窄发生有较高的预测价值,有助于临床早干预、早治疗。
Objectives This study aims to explore the predictive value of the combined detection of ET-1,sTREM-1, and VEGF levels in patients with ASO after vascular intervention in the occurrence of vascular restenosis, so as to provide a reference for the diagnosis and treatment of vascular restenosis after vascular intervention in patients with ASO.Methods A total of 103 patients with lower extremity ASO admitted from January 1, 2018 to October 1, 2020 were selected for vascular intervention. According to whether they had vascular restenosis one year after surgery, they were divided into the non-occurring group(n=72) and the occurrence group(n=31). The basic conditions of the two groups and the levels of serum ET-1, sTREM-1, and VEGF were compared. The logistic regression model was used to analyze the univariate and multivariate analysis of vascular restenosis in patients with lower extremity ASO after vascular intervention, and the receiver operating characteristic curve(ROC) was used to analyze serum ET-1, sTREM-1, and VEGF to predict the value of postoperative restenosis of blood vessels after vascular intervention in patients with lower extremity ASO.Results The levels of ET-1, sTREM-1, and VEGF in the occurrence group were significantly higher than those in the non-occurrence group(P<0.05). Single-factor logistic regression analysis showed that serum uric acid(SUA), fibrinogen(FIB),low-density lipoprotein cholesterol(LDL-C), ET-1, sTREM-1, VEGF levels were related to the occurrence of vascular restenosis(P< 0.05). Further multivariate logistic regression analysis showed that high levels of ET-1,sTREM-1, and VEGF were risk factors for the occurrence of vascular restenosis(P<0.05). The ROC curve showed that when the best cut-off values of ET-1, sTREM-1, and VEGF were 328.66 pg/mL, 179.89 ng/L, and 72.80 pg/mL. The combined predicted AUC was 0.897 with the sensitivity of 90.31 and specificity of 76.40.Conclusions The combined detection of serum ET-1, sTREM-1, and VEGF levels after vascular intervention in lower limb ASO patients has a high predictive value for the occurrence of vascular restenosis, which is helpful for early clinical intervention and early treatment.
作者
田浩
郑翔
闻作川
王永平
刘冠群
王辉
Tian Hao;Zheng Xiang;Wen Zuochuan;Wang Yongping;Liu Guanqun;Wang Hui(Department of Thoracic V ascular Surgery,Capital Medical University Daxing Teaching Hospital,Beijing 102600,China;不详)
出处
《中国病案》
2023年第1期106-109,共4页
Chinese Medical Record
关键词
下肢动脉硬化闭塞症
血管介入术
血管内皮生长因子
内皮素-1
可溶性髓系细胞触发受体1
血管再狭窄
预测价值
Lower extremity arteriosclerosis obliterans
Vascular intervention
Vascular endothelial growth factor
Endothelin-1
Soluble myeloid cell trigger receptor 1
Vascular restenosis
Predictive value
作者简介
通信作者:王辉。
