摘要
缺血性心脏病现已成为心血管疾病的主要死因。中药地黄具有清热养血、养阴生津等功效,梓醇是从地黄中提取出来的一种活性成分,近年来梓醇在治疗缺血性心脏病方面显示出了潜在的治疗作用。文章从抗氧化应激、抗炎、抑制细胞凋亡、促进自噬等方面,对梓醇保护缺血性心脏病的机制进行综述。以期为梓醇的临床应用和新药研发提供依据。
Ischemic heart disease is now the leading cause of death from cardiovascular disease.The Chinese herb Dihuang has the ability to clear heat and nourish blood,nourish yin and produce fluid.Catalpol is an active ingredient extracted from Dihuang,which has shown potential therapeutic effects in the treatment of ischemic heart disease in recent years.The article reviews the mechanism of catalpol’s protection against ischemic heart disease in terms of anti-oxidative stress,anti-inflammation,inhibition of apoptosis and promotion of autophagy.It is expected to provide a basis for the clinical application and new drug development of catalpol.
作者
林立志
尹晓荣
申程
曹勇
LIN Li-zhi;YIN Xiao-rong;SHEN Cheng;CAO Yong(Clinical Medical College of Jining Medical University,Jining 272000,China;Department of Cardiology,Coronary Heart Disease Second Ward,Affiliated Hospital of Jining Medical College,Jining 272000,China)
出处
《中国心血管病研究》
CAS
2023年第3期219-223,共5页
Chinese Journal of Cardiovascular Research
关键词
缺血性心脏病
梓醇
氧化应激
凋亡
炎症
Ischemic Heart Disease
Catalpol
Oxidative Stress
Apoptosis
Inflammation
作者简介
通信作者:曹勇,E-mail:caoyong0149@163.com。
