摘要
目的:采用电感耦合等离子体质谱(ICP-MS)法测定中药白术铜、铅、砷、镉、汞5种重金属的含量,并根据测定结果进行健康风险评估。方法:样品经微波消解后,以锗、铟、铋为内标,进行ICP-MS测定铜(Cu)、铅(Pb)、砷(As)、镉(Cd)、汞(Hg)5种元素,根据测定结果采用靶标危害系数法(THQ)进行健康风险评估。结果:Cu、Pb、As、Cd和Hg 5种待测元素的线性关系良好(r≥0.999 2),回收率为88.8%~108.4%;RSD的范围为2.2%~5.4%。风险评估结果显示白术中的重金属及有害元素所致安全性风险较低。结论:该方法为中药白术中的重金属及有害元素测定和风险评估提供了科学依据。
Objective:The five heavy metals of Cu, Pb, As, Cd and Hg in Atractylodis Macrocephalae Rhizoma were determined by plasma mass spectrometry(ICP-MS), and the risk assessment was carried out according to the determination results.Methods:After microwave digestion, the samples were determined by ICP-MS with germanium, indium and bismuth as internal standards, and the five elements of Cu, Pb, As, Cd, Hg were determined. According to the determination results, the target hazard quotients(THQ) method was used for health risk assessment. Results: The linear relationships of Cu, Pb, As, Cd, Hg were good(r≥0.999 2), and the recovery were 88.8%-108.4%. RSD ranges from 2.2% to 5.4%. The results of risk assessment showed that the contents of heavy metals and harmful elements in Atractylodis Macrocephalae Rhizoma were low risk to human health. Conclusion: This method provides scientific basis for the determination and risk assessment of heavy metals and harmful elements in Atractylodis Macrocephalae Rhizoma.
作者
李飞飞
谢晓玲
陈新阳
昝珂
赵磊
LI Fei-fei;XIE Xiao-ling;CHEN Xin-yang;ZAN Ke;ZHAO Lei(Guangzhou Baiyunshan Zhongyi Pharmaceutical Company Limited,Guangdong Guangzhou 510530,China;National Institutes for Food and Drug Control,Beijing,102629,China;Siping Institute food and Drug Control,Jilin Siping 136000,China;Changchun University of traditional Chinese Medicine School of Medicine,Jilin Changchun 130117,China)
出处
《中国药物评价》
2023年第1期54-57,共4页
Chinese Journal of Drug Evaluation
关键词
白术
电感耦合等离子体质谱
重金属及有害元素
健康风险评估
Atractylodis Macrocephalae Rhizoma
Inductively coupled plasma mass spectrometry(ICP-MS)
Heavy metals and harmful elements
Health risk assessment
作者简介
李飞飞,女,硕士,制药工程师,研究方向:中药质量控制。E-mail:149809338@qq.com;通讯作者:昝珂,男,博士,副研究员,研究方向:中药标准及质量评价。E-mail:6206310@qq.com;英国警示度普利尤单抗的眼部不良反应风险并建议及时管理赵磊,男,博士,主任药师,研究方向:中药质量控制研究。E-mail:zhaolei0433@sina.com。
