摘要
目的 观察阿司匹林联合地屈孕酮对肥胖型多卵巢综合征(PCOS)患者子宫内膜容受性(ER)及胰岛素抵抗(IR)的影响。方法 选取我院收治的110例肥胖型PCOS患者作为研究对象,依据随机数表法分成实验组和对照组各55例。对照组给予地屈孕酮治疗,实验组在对照组方案上联合阿司匹林治疗。观察治疗前及治疗1个周期后两组患者性激素水平[睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)]、ER超声学检查指标[子宫内膜厚度、子宫动脉血流搏动指数(PI)、阻力指数(RI)]和胰岛素指标[胰岛素抵抗指数(HOMA-IRI)、胰岛素分泌功能指数(HOMA-β)]变化,分析疗程中两组患者药物不良反应总发生率及治疗后半年内两组患者受孕率差异。结果 治疗1个周期后,两组患者性激素水平(T、LH、FSH)、ER超声学检查指标(PI、RI)和胰岛素指标(HOMA-IRI、HOMA-β)均较治疗前显著降低,且实验组明显低于同一时间对照组(均P<0.05);两组患者子宫内膜厚度均较治疗前显著升高,且实验组明显高于同一时间对照组(均P<0.05)。疗程中,两组患者药物不良反应总发生率差异无统计学意义(P>0.05)。治疗后半年内,实验组受孕率明显高于同一时间对照组(P<0.05)。结论 阿司匹林联合地屈孕酮应用于肥胖型PCOS患者治疗可获得良好效果,性激素水平趋于下降,ER随之提升,胰岛素分泌减少,能增加患者受孕率,且药物安全性良好,值得临床普及应用。
Objective To observe the effects of aspirin combined with dydrogesterone on endometrial receptivity(ER)and insulin resistance(IR)in patients with obesity polyovary syndrome(PCOS).Methods 110 cases of obese PCOS patients treated in our hospital were selected as the research objects,and they were divided into experimental group and control group with 55 cases each according to the random number table method.The control group was treated with dydrogesterone,and the experimental group was treated with aspirin in the control group.Before and after one cycle of treatment,observe the levels of sex hormones [testosterone(T),luteinizing hormone(LH),follicle stimulating hormone(FSH)],ER ultrasound examination indicators [Endometrial thickness,uterine artery blood flow pulsation index(PI),resistance index(RI)] and insulin index [insulin resistance index(HOMA-IRI),insulin secretion function index(HOMA-β)] of the two groups.The total incidence of adverse drug reactions in the two groups during the course of treatment and the difference in the pregnancy rates of the two groups within six months after treatment were analyzed.Results After one cycle of treatment,the levels of sex hormones(T,LH,FSH),ER ultrasound examination indicators(PI,RI),and insulin indicators(HOMA-IRI,HOMA-β)in the two groups were significantly lower than before treatment.And the experimental group was significantly lower than the control group at the same time(both P0.05).Within six months after treatment,the pregnancy rate in the experimental group was significantly higher than that in the control group at the same time(P<0.05).Conclusions Aspirin combined with dydrogesterone can achieve good results in the treatment of obese PCOS patients.Sex hormone levels tend to decrease,ER will increase,and insulin secretion will decrease.It can increase the pregnancy rate of patients,and the drug is safe,which is worthy of clinical popularization.
作者
魏春花
李海艳
朱淑平
Wei Chunhua;Li Haiyan;Zhu Shuping(Sui County Hospital of Traditional Chinese Medicine,Henan 476900,China)
出处
《哈尔滨医药》
2023年第1期56-58,共3页
Harbin Medical Journal
