摘要
冬凌草为唇形科香茶属植物,性微寒,有活血止痛、解热降噪和清热解毒的功效,近年来研究发现其主要活性成分冬凌草甲素具有降压、抗氧化、抗菌、抗肿瘤、抗凋亡、增强机体免疫等多种药理作用。基于现代医学研究,从核因子κB(NF-κB)、丝裂原活化蛋白激酶(MAPK)和NOD样受体热蛋白结构域相关蛋白3(NLRP3)等信号通路方面,对冬凌草甲素在呼吸系统炎症、消化系统炎症、神经性炎症、肾损伤性炎症、血管炎等疾病抗炎作用机制的研究进展进行综述,为研究与开发以冬凌草甲素为原料的抗炎新药提供参考。
Rabdosia rubescens is a plant of the Labiatae family. It is mildly cold and has the function of promoting blood circulation and relieving pain, relieving heat and detoxifying, In recent years, studies have been found that its main active ingredient oridonin has a variety of pharmacological effects, such as antihypertensive, antioxidant, antibacterial, anti-tumor, anti-apoptosis and enhancing the body′s immunity. Based on modern medical research, from the nuclear factor κB(NF-κB), mitogen-activated protein kinase(MAPK), NOD receptor heat protein domain associated protein 3(NLRP3) signaling pathways, we reviewed the the research progress of anti-inflammatory mechanisms of oridonin in respiratory system, digestive system nervous system, kidney injury and vascular diseases, which would provide evidence for the research and development of new anti-inflammatory drugs based on oridonin.
作者
李彩芸
陈旭雯
岳飞燕
Sani Ibrahim
张艳
岳嘉
朱向东
樊景春
Li Caiyun;Chen Xuwen;Yue Feiyan;Sani Ibrahim;Zhang Yan;Yue Jia;Zhu Xiangdong;Fan Jingchun(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000 China;School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000 China;Traditional Chinese Medicine School of Ningxia Medical University,Yinchuan 750004,China;Lab.and Simulation Training Center,Gansu University of Chinese Medicine,Lanzhou 730000 China;Evidence‑based Medical Center,Gansu University of Chinese Medicine,Lanzhou 730000,China;Collaborative Innovation Center for TCM Prevention and Control of Environmental and Nutrition‑related Diseases in Northwest China,Lanzhou 730000,China)
出处
《中国野生植物资源》
CSCD
2023年第2期88-93,共6页
Chinese Wild Plant Resources
基金
2020年兰州市城关区科技计划项目(2020-2-11-16)
甘肃中医药大学引进人才科研启动基金项目(2016YJRC-01)
兰州市科技局2019年度人才创新创业项目(2019-RC-100)
2022年度甘肃省优秀研究生“创新之星”项目(2022CXZX-752)
甘肃省卫生行业科研管理项目(GSWSKY2021-058)
吴阶平医学基金项目(320.6750.2022-20-21)。
作者简介
李彩芸(1994-),女,甘肃平凉人,硕士研究生,主要研究方向为慢性非传染性疾病流行病学。E-mail:1511863529@qq.com;通讯作者:樊景春(1979-),女,甘肃庆阳人,副教授,博士,研究方向为慢性病流行病学。E-mail:fan-jc@126.com;共同通讯作者:朱向东(1973-),男,内蒙兴安盟人,教授,博士,研究方向为中医药防治糖尿病。E-mail:zhuxiangdong33@163.com。
