摘要
胃癌是世界上发病率较高的恶性肿瘤之一,香砂六君子汤是防治胃癌常用方,具有行气止痛、燥湿健脾之功,尤宜于胃癌脾胃气虚证。笔者通过检索知网、万方、PubMed等数据库,对香砂六君子汤防治胃癌的临床疗效和实验研究进行整合与梳理,阐述香砂六君子汤防治胃癌的作用机制,以期为今后开展香砂六君子汤在胃癌领域的临床和基础研究方面提供有益参考。在临床中,香砂六君子汤具有治疗胃癌前病变、提高胃癌患者机体免疫、改善胃癌术后脾胃虚弱症状、减轻胃癌化疗后消化道不良反应等作用,无论与西药联用或单独使用,临床疗效均优于单纯西药治疗。在实验研究中,香砂六君子汤具有调节炎症因子、抑制胃癌细胞增殖、促进胃癌细胞凋亡、提高胃蛋白酶活性等作用。现代药理学研究表明,香砂六君子汤可通过多成分、多靶点综合干预,其单味药主要成分包括皂苷类、多糖类、内酯类、挥发油类、有机酸类等,具有保护胃黏膜、调节内分泌、促进胃黏膜异型增生的上皮细胞凋亡等作用,体现了中医药防治胃癌的优势与价值。
Gastric cancer is one of the malignancies with high incidence in the world. Xiangsha Liu Junzitang,a common prescription for the prevention and treatment of gastric cancer,has the effects of moving Qi to relieve pain,drying dampness, and invigorating the spleen. It is especially indicated for gastric cancer of the spleen and stomach qi deficiency syndrome. Based on the databases such as CNKI,Wanfang Data,and PubMed,the clinical efficacy and experimental studies of Xiangsha Liu Junzitang for the prevention and treatment of gastric cancer were summarized and sorted out,and the mechanism of Xiangsha Liu Junzitang for the prevention and treatment of gastric cancer was elaborated in order to provide useful references for the clinical and basic research on Xiangsha Liu Junzitang in the field of gastric cancer in the future. In clinical practice,Xiangsha Liu Junzitang can treat gastric precancerous lesions,increase the body immunity of patients with gastric cancer,improve the symptoms of spleen and stomach weakness after gastric cancer surgery,and reduce the adverse reactions of the digestive tract after chemotherapy for gastric cancer. Its clinical efficacy is superior to that of western medicine alone whether it is combined with western medicine or used alone. In the experimental research,Xiangsha Liu Junzitang has the effects of regulating inflammatory factors,inhibiting the proliferation of gastric cancer cells,promoting the apoptosis of gastric cancer cells,and improving the activity of pepsin. Modern pharmacological research has shown that Xiangsha Liu Junzitang can conduct a comprehensive intervention with multiple components and multiple targets. The main components of a single drug contained include saponins,polysaccharides,lactones,volatile oils,organic acids,and others, with the effects of protecting gastric mucosa,regulating endocrine,and promoting apoptosis of epithelial cells in gastric mucosal dysplasia,reflecting the advantages and values of traditional Chinese medicine in the prevention and treatment of gastric cancer.
作者
周恩慧
许二平
张楠
康丽杰
张明远
龙天键
马征
ZHOU Enhui;XU Erping;ZHANG Nan;KANG Lijie;ZHANG Mingyuan;LONG Tianjian;MA Zheng(Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第4期221-227,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81973739)
河南省中医药科学研究专项课题项目(2019ZY1019)
河南省高等学校青年骨干教师培养计划(2021GGJS087)。
关键词
胃癌
香砂六君子汤
临床疗效
实验研究
药理作用
gastric cancer
Xiangsha Liu Junzitang
clinical efficacy
experimental research
pharmacological action
作者简介
第一作者:周恩慧,医学硕士,从事方剂配伍及作用机制规律研究,E-mail:1031180314@qq.com;通信作者:许二平,博士,教授,博士生导师,从事方剂配伍及作用机制规律研究,E-mail:xuerping1228@163.com;通信作者:张楠,博士,副教授,从事方剂配伍及作用机制规律研究,E-mail:zhangnan@hactcm.edu.cn。
