摘要
目的 分析影响更年期糖尿病患者并发亚临床甲状腺功能减退的因素及其预防措施。方法 回顾性收集更年期糖尿病患者360例的临床资料,根据患者是否并发亚临床甲状腺功能减退将其分为并发组(98例)和未并发组(262例)。采用单因素分析法分析并发组和未并发组的一般资料,采用多因素Logistic回归分析法分析更年期糖尿病患者并发亚临床甲状腺功能减退的危险因素。结果 并发组病程长于未并发组(P<0.05);并发组血清尿酸(SUA)、血浆超敏C反应蛋白(hs-CRP)、糖化血红蛋白(Hb A1C)水平高于未并发组(P<0.05),血清高密度脂蛋白胆固醇(HDL-C)、雌二醇(E2)水平低于未并发组(P<0.05)。多因素Logistic回归分析结果显示,血浆Hb A1C水平高、血清E2水平低是更年期糖尿病患者并发亚临床甲状腺功能减退的独立危险因素(OR=1.309;1.380,P<0.05)。结论 更年期糖尿病患者并发亚临床甲状腺功能减退的危险因素包括血浆Hb A1C水平高、血清E2水平低等,临床可据此对更年期糖尿病患者采取合理的措施进行治疗和护理。
Objective To analyze the risk factors af fecting the complication with subclinical hypothyroidism in menopausal patients with diabetes and their preventive measures. Methods The clinical data of 360 menopausal patients with diabetes admitted to the Jianli People’s Hospital of Hubei province from December 2016 to December 2019 were retrospectively collected, and they were divided into a concurrent group(98 cases) and a non-concurrent group(262 cases) according to whether they were complicated with subclinical hypothyroidism. The general data of the concurrent and the non-concurrent groups were analyzed with a univariate analysis, and the risk factors for subclinical hypothyroidism in the menopausal patients with diabetes were analyzed with a multivariate Logistic regression analysis. Results The course of disease in the concurrent group was longer than that in the non-concurrent group(P<0.05). The levels of serum uric acid(SUA), plasma hypersensitive C-reactive protein(hs-CRP) and glycosylated hemoglobin(HbA1C) were higher in the concurrent group than those in the non-concurrent group(P<0.05), while the levels of serum high density lipoprotein cholesterol(HDL-C) and estradiol(E2) were lower than those in the non-concurrent group(P<0.05). The multivariate Logistic regression analysis showed that the high level of plasma HbA1C and low level of serum E2 were independent risk factors for subclinical hypothyroidism in menopausal patients with diabetes(OR=1.309;1.380, P<0.05).Conclusion The risk factors for subclinical hypothyroidism in menopausal patients with diabetes include the high level of plasma HbA1C and low level of serum E2. Based on the two risk factors, reasonable treatment and nursing measures should be taken for menopausal diabetes patients to avoid the complication of subclinical hypothyroidism in them.
作者
张付生
杨俊
ZHANG Fusheng;YANG Jun(Department of Endocrinology,Jianli People's Hospital,Jianli 433300,China)
出处
《长春中医药大学学报》
2023年第2期201-204,共4页
Journal of Changchun University of Chinese Medicine
基金
国家卫生健康委“十四五”规划全国重点课题(YYWS3574)。
关键词
糖尿病
更年期
亚临床甲状腺功能减退
危险因素
预防对策
diabetes
climacteric period
subclinical hypothyroidism
risk factors
preventive countermeasures
作者简介
张付生(1987—),男,主治医师,主要从事内分泌方向研究;通信作者:杨俊,男,副主任医师,电子信箱:yangj-999@163.com。
