摘要
目的探讨2型糖尿病(T2DM)患者糖化血红蛋白变异指数(HGI)与糖尿病肾病(DN)的相关性。方法选取2015年1月~2019年10月于我科住院的T2DM患者450例,根据HGI将其分为低HGI组(150例)、中HGI组(150例)、高HGI组(150例),比较3组患者的临床资料、实验室检查结果及HGI,采用logistic回归分析探讨T2DM发生DN的影响因素,比较3组患者发生DN的风险。结果3组患者的糖尿病病程、糖化血红蛋白(HbA1c)、血肌酐(SCr)、肌酐清除率(Ccr)、血尿酸(UA)、血清视黄醇结合蛋白(RBP)、低密度脂蛋白胆固醇(LDL-C)比较差异均有统计学意义(P<0.05)。单因素logistic回归分析结果显示,年龄、收缩压(SBP)、舒张压(DBP)、糖尿病病程、空腹血糖(FPG)、HbA1c、HGI、SCr、Ccr、UA、RBP、LDL-C与DN相关(P<0.001)。多因素logistic回归分析结果显示,中HGI组患者发生DN的风险是低HGI组的1.822倍(OR=1.822,95%CI 1.149~2.890,P=0.011),高HGI组T2DM患者发生DN的风险是低HGI组的4.049倍(OR=4.049,95%CI 2.435~6.734,P<0.001)。结论高HGI的T2DM患者发生DN风险增加。
Objective To investigate the relationship between hemoglobin glycation index(HGI)and diabetic nephropathy(DN)of type 2 diabetes mellitus(T2 DM).Methods A total of 450 patients with T2 DM were collected from January 2015 to Octorber 2019 in our department were divided into low HGI group(150 cases),moderate HGI group(150 cases)and high HGI group(150 cases)according to the HGI.Clinical data,laboratory results and HGI were compared among patients in the 3 groups.Logistic regression analysis was used to explore the influencing factors of the occurrence of DN in T2 DM,and to compare the risk of the occurrence of DN among the 3 groups.Results The course of diabetes mellitus,glycosylated hemoglobin(HbA1 c),serum creatinine(SCr),the creatinine clearance(Ccr),serum uric acid(UA),serum retinol binding protein(RBP),low density lipoprotein cholesterol(LDL-C)were significant different among the 3 groups(P<0.05).Sigle logistic regression analysis showed that age,systolic blood pressure(SBP),diastolic blood pressure(DBP),course of diabetes mellitus,fasting plasma glucose(FPG),HbA1 c,HGI,SCr,Ccr,UA,RBP and LDL-C were related with DN(P<0.001).Multivoriate logistic regression analysis showed that the risk of DN in the moderate HGI group was 1.822 times higher than that in the low HGI group(OR=1.822,95%CI 1.149-2.890,P=0.011).The risk of DN occurrence in the high HGI group was 4.049 times higher than that in the low HGI group(OR=4.049,95%CI 2.435-6.734,P<0.001).Conclusion The risk of DN occurrence increases in T2 DM patients with high HGI level.
作者
雷程灏
尹倩
朱叶
Lei Chenghao;Yin Qian;Zhu Ye(Department of Endocrinology,Nanjing Gulou Hospital Group Gaoxin Hospital,Nanjing 210032,China)
出处
《临床内科杂志》
CAS
2022年第6期396-399,共4页
Journal of Clinical Internal Medicine
