摘要
目的探讨鼻咽癌患者中医体质类型分布与临床病理特征的关联性,为鼻咽癌的中医个性化治疗提供依据。方法收集广西壮族自治区人民医院收治的58例鼻咽癌患者的临床资料,分析鼻咽癌患者的中医体质类型与临床特征关系。结果58例初治鼻咽癌患者中偏颇体质占68.97%(40/58)。鼻咽癌患者中医体质类型的临床分期分布情况差异有统计学意义(P<0.05)。随着临床分期的增加,EBV-DNA阳性率呈上升的趋势。治疗结束时,平和质患者完全缓解(CR)13例,部分缓解(PR)5例;偏颇体质患者CR 21例,PR 19例,差异无统计学意义(Z=1.399,P=0.162)。平和质患者2年无瘤生存率为100.00%,偏颇体质患者2年无瘤生存率为81.20%,差异无统计学意义(P=0.068)。结论特定的中医体质类型与鼻咽癌发生和发展存在关联性,并可能随着EB病毒的复制和病情的进展发生改变。
Objective To explore the correlation between the distribution of Traditional Chinese Medicine(TCM)constitutional types and clinical pathological characteristics in patients with nasopharyngeal carcinoma(NPC),and to provide evidence for personalized TCM treatment for NPC.Methods The clinical data of 58 NPC patients treated in the People′s Hospital of Guangxi Zhuang Autonomous Region were collected to analyze the relationship between TCM constitutional types and clinical characteristics in the NPC patients.Results Among the 58 patients with newly diagnosed NPC,unbalanced constitution accounted for 68.97%(40/58).There was significant difference in the clinical stage distribution between the nasopharyngeal carcinoma patients with different TCM constitutional types(P<0.05).The Epstein-Barr virus-deoxyribonucleic acid(EBV-DNA)positivity rate tended to increase with increasing clinical stage.Thirteen cases achieved complete remission(CR)and 5 cases achieved partial remission(PR)at the end of treatment in the balanced constitution patients,and 21 cases achieved CR and 19 cases achieved PR in the unbalanced constitution patients,with no significant differences between the two groups of patients(Z=1.399,P=0.162).The 2-year disease-free survival rate was 100.00%in the balanced constitution patients and 81.20%in the unbalanced constitution patients,with no significant difference between the two groups of patients(P=0.068).Conclusion Specific TCM constitutional types are correlated with the occurrence and development of NPC,and may change with the replication of EBV and the progression of the disease.
作者
翁敬锦
韦嘉章
韦云钟
李敏
王汉伟
桂志
董国虎
熊伟明
江河
瞿申红
WENG Jing-jin;WEI Jia-zhang;WEI Yun-zhong(Department of Otolaryngology&Head and Neck,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)
出处
《中国临床新医学》
2023年第1期8-12,共5页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广西中医药适宜技术开发与推广项目(编号:GZSY21-52)
广西科技基地和人才专项基金项目(编号:桂科AD20297069)。
关键词
鼻咽癌
中医体质
临床分期
病因
EB病毒
Nasopharyngeal carcinoma
Traditional Chinese Medicine(TCM)constitution
Clinical staging
Etiology
Epstein-Barr virus
作者简介
翁敬锦,医学博士,副主任医师,硕士研究生导师,研究方向:鼻咽癌的诊治。E-mail:wengjingjin@126.com;通信作者:瞿申红,医学博士,主任医师,博士研究生导师,研究方向:鼻咽颅底疾病的诊治。教授,博士研究生导师。广西壮族自治区人民医院(广西医学科学院)东院副院长,广西壮族自治区人民医院耳鼻咽喉头颈科主任。先后在纽约州立大学、迈阿密大学医院耳鼻咽喉头颈外科、宾夕法尼亚大学医院耳鼻咽喉头颈外科做博士后、专科医师训练和访问学者。先后任中国医疗保健促进会耳鼻咽喉头颈外科分会广西组长、中国中西医结合耳鼻咽喉头颈外科变态反应专业委员会常务委员、广西医学会耳鼻咽喉头颈外科分会副主任委员、广西中西医结合耳鼻咽喉头颈外科分会副主任委员,139培养人才,广西科技厅评审专家。对耳鼻咽喉头颈外科疾病诊断和治疗具有扎实的专业理论知识和丰富的临床经验,擅长鼻咽颅底、耳侧颅底外科。主持国家自然科学基金项目和广西自然科学基金项目及重点研发项目等6项。以第一作者或通信作者在SCI收录和国内专业核心期刊等发表论文40多篇。E-mail:qshdoctor@163.com。
