摘要
目的:观察经典名方开心散防治2型糖尿病(T2DM)认知障碍的临床疗效,初步研讨基于脾散精藏神理论指导下开心散发挥治疗作用的机制。方法:84例2型糖尿病认知障碍患者随机分为两组,每组42例。对照组仅给予常规治疗,治疗组则在对照组治疗方案的基础之上加服开心散。治疗6个月后,比较两组的认知功能评分、血糖控制、波动情况,观察比较两组研究对象治疗前后的安全性指标。结果:两组患者临床有效率比较,对照组有效率为61.90%(26/42),治疗组有效率85.71%(36/42),治疗组有效率较对照组明显增高,差异有统计学意义(P=0.013)。评分表比较显示,MMSE量表评分比较,治疗组治疗后评分显著增加(P<0.05)。MoCA量表评分比较,治疗组治疗后评分较对照组治疗后显著增加(P<0.05),其中在视空间和执行能力、注意力、延迟回忆等3方面治疗组MoCA测评分数较对照组均显著升高(P<0.05)。血糖相关指数结果显示治疗组治疗后LAGE、早餐PPGE、MAGE、MODD、糖化血红蛋白水平较对照组治疗后明显改善(P<0.05)。结论:经典名方开心散可显著改善T2DM认知障碍,临床疗效显著,其作用机制可能是通过改善糖尿病患者血糖的波动幅度实现的。
Objective:To observe the clinical efficacy of Kaixin Powder in treatment of cognitive impairment of type 2 diabetes mellitus(T2DM)and to explore its mechanism under the theory of Spleen dispersing essence and storing Shen.Methods:84 patients with T2DM cognitive impairment were randomly divided into the control group and the treatment group,with 42 patients in each group.The control group was given routine treatment;on which basis,the treatment group was also treated with Kaixin Powder.After 6 months of treatment,cognitive function scores,blood glucose control and fluctuation,as well as safety indexes were compared between the two groups.Results:The effective rate of the treatment group was 85.71%(36/42),which was significantly higher than 61.90%(26/42)of the control group(P=0.013).The MMSE score was significantly increased after the treatment compared with that before the treatment in the treatment group(P<0.05).The scores of MoCA,in terms of visual space,executive ability,attention and delayed recall,were significantly higher in the treatment group than those in the control group after the treatment(P<0.05).The results of blood glucose related indexes showed that LAGE,PPGE,MAGE,MODD and glycosylated hemoglobin were significantly improved in the treatment group compared with those in the control group(P<0.05).Conclusion:Kaixin Powder can improve cognitive impairment of T2DM with significant clinical efficacy,and its mechanism may be related to improving the fluctuation range of blood glucose.
作者
龙运红
李玲
赵凌霄
呼兴华
LONG Yunhong;LI Ling;ZHAO Lingxiao;HU Xinghua(Shaanxi University of Chinese Medicine,Xianyang 712000,China;Shaanxi Provincial Hospital of Chinese Medicine,Xi'an 710000,China)
出处
《中医药学报》
CAS
2023年第2期62-67,共6页
Acta Chinese Medicine and Pharmacology
基金
国家重点研发计划项目(2018YFC2002500)
北京中医药大学孙思邈研究院中医药科研计划项目(SSMYJY-2-2020-13)。
关键词
脾散精藏神理论
糖尿病认知障碍
开心散
血糖波动
临床疗效
Theory of Spleen dispersing essence and storing Shen
Diabetic cognitive impairment
Kaixin Powder
Blood glucose fluctuation
Clinical efficacy
作者简介
龙运红(1993-),女,硕士研究生,研究方向:糖尿病认知障碍的中医药防治;通讯作者:李玲(1983-),女,博士,副主任医师,硕士生导师,研究方向:老年性痴呆与代谢性疾病之间的关系。
