摘要
目的观察厌食康颗粒治疗小儿厌食症脾失健运证的临床疗效及安全性。方法选取2020年12月1日—2021年5月30日期间广西中医药大学第一附属医院、广西中医药大学附属瑞康医院、广西壮族自治区妇幼保健院收治的300例小儿厌食症脾失健运证患儿,按2∶1比例分为治疗组200例和对照组100例。治疗组服用厌食康颗粒,对照组服用儿康宁糖浆,治疗2周后,观察比较两组患儿临床疗效、中医证候疗效的改善情况和用药安全性。结果治疗后对照组总有效率90.00%(90/100)与治疗组91.50%(183/200)比较,差异无统计学意义(P>0.05)。治疗后两组患儿中医证候评分均较治疗前降低,差异有统计学意义(P<0.05);两组患儿中医证候评分组间比较,差异无统计学意义(P>0.05),疗效相当。治疗后治疗组食欲、食量改善率均为91.00%,嗳气恶心改善率为94.24%;对照组食欲、食量改善率均为91.00%,嗳气恶心改善率为94.12%。两组患儿食欲、食量、嗳气恶心改善率比较,差异无统计学意义(P>0.05)。治疗期间,两组患儿血常规、尿常规、大便潜血,以及心、肝、肾功能均未发现不良反应,表明厌食康颗粒具有较好的安全性,适合儿童群体服用。结论厌食康颗粒选用药食同源药材,治疗小儿厌食症脾失健运证,临床疗效好,且具有较高的安全性。
Objective To observe the clinical efficacy and safety of Yanshikang Granules in treating infantile anorexia with syndrome of dysfunction of spleen in transportation.Methods A total of 300 children with anorexia of the syndrome of dysfunction of spleen in transportation who were treated in The First Affiliated Hospital of Guangxi University of Chinese Medicine,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,and Maternity and Child Health Center of Guangxi Zhuang Autonomous Region from December 1,2020 to May 30,2021 were enrolled,and classified into the treatment group(n=200)and control group(n=100).The treatment group received Yanshikang Granules and the control group was treated with Erkangning Syrup.The treatment lasted 2 weeks for both groups.Then,the clinical efficacy,improvementof traditional Chinese medicine(TCM)syndrome,and the safety of the drugs were compared between the two groups.Results The total effective rate was 90.00%(90/100)in the control group and 91.50%(183/200)in the treatment group(P>0.05).After treatment,the TCM syndrome score was lower than that before treatment in both groups(P<0.05),and the difference in the score between the two groups was insignificant(P>0.05).The improvement rate of appetite and food intake and that of belching and nausea were 91.00%and 94.24%in the treatment group,respectively,while the corresponding figures were 91.00%and 94.12%,separately.The improvement rates of the above symptoms showed no significant difference between the two groups(P>0.05),indicating that the efficacy of Yanshikang Granules was comparable to that of the positive drug.No abnormality was found in the blood routine examination,routine urine test,or fecal occult blood test of the two groups,and no adverse reactions in the heart,liver,or kidney were observed in the two groups.Thus,Yanshikang Granules was safe and can be used for anorexia in children.Conclusion Yanshikang Granule is used to treat the spleen deficiency syndrome of children with anorexia.It has good clinical efficacy and high safety.
作者
覃耀真
王丹宜
QIN Yao-zhen;WANG Dan-yi(The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning Guangxi 530000)
出处
《世界中西医结合杂志》
2022年第11期2211-2214,共4页
World Journal of Integrated Traditional and Western Medicine
基金
广西壮族自治区卫生厅自筹经费科研课题(Z2011123)。
关键词
小儿厌食症
脾失健运证
厌食康颗粒
多中心临床研究
Infantile Anorexia
Dysfunction of Spleen in Transportation Syndrome
Yanshikang Granules
Multi-Center Clinical Research
作者简介
通信作者:覃耀真,Email:nnqyz@163.com。
