摘要
近年来,中药引起的神经毒性时有发生,已成为制约中药开发与应用重要因素之一。中药所含活性成分及其量效关系是决定其药理活性和毒性作用的关键,其中,内源性毒性成分包括生物碱、糖苷类、二萜类、动植物毒蛋白和重金属等,外源性毒性成分则主要是指在药材种植、加工、运输、存储过程中引入的一些非本身合成的有害元素和农药残留。中药对氧化应激、炎症、离子交换、能量代谢等过程的影响可能是其致神经毒性的重要机制。神经细胞、髓鞘细胞、轴索和神经递质系统是中药致神经毒性的常见靶标。今后可考虑利用现代研究方法和大数据挖掘手段,建立以毒性物质基础成分群为核心的“中毒症状-中毒剂量-中毒原药-解毒方案”的安全性评价模式,从而为神经毒性中药的开发利用及临床干预提供支撑。
In recent years,neurotoxicity caused by traditional Chinese medicine(TCM)has frequently occurred and has become one of the important factors restricting the development and application of TCM.TCM contains active components and its dosage-effect relationship is the key to determine its pharmacological activity and toxic effects.Among them,the endogenous toxic components include alkaloids,glycosides,diterpenoids,animal and plant toxic proteins and heavy metals,and so on;exogenous toxic components mainly refer to some harmful elements and pesticide residues during the cultivation,processing,transportation and storage of medicinal materials that are not synthesized by themselves.Effect on the processes such as oxidative stress,inflammation,ion exchange,and energy metabolism may be important mechanisms of TCM-induced neurotoxicity.Neural cells,myelin cells,axons and neurotransmitter systems are common targets of TCM-induced neurotoxicity.In the future,we can use modern research methods and big data mining means to establish a safety evaluation mode of“toxic symptoms-poisoning dose-toxic original agent-detoxification scheme”with the basic component group of toxic substances as the core,so as to provide support for development and clinical intervention of neurotoxic traditional Chinese medicine.
作者
何海
赵沙沙
邢耀莹
王姿杨
杜丽东
邵晶
HE Hai;ZHAO Shasha;XING Yaoying;WANG Ziyang;DU Lidong;SHAO Jing(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Northwest Collaborative Innovation Center for Traditional Chinese Medicine and Tibetan Medicine Co-constructed by Gansu Province&MOE of PRC,Lanzhou 730000,China;Gansu Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine,Lanzhou 730000,China)
出处
《中国药房》
CAS
北大核心
2023年第2期251-256,共6页
China Pharmacy
基金
甘肃省科技计划项目(No.21JR11RA136)
甘肃省药品监督管理局科研项目(No.2022GSMPA003)
甘肃省教育科技创新项目青年博士基金项目(No.2022QB-090)
甘肃省教育厅“双一流”重大科研项目(No.GSSYLXM-05)。
关键词
中药
神经毒性
物质基础
作用机制
靶点
毒性成分
traditional Chinese medicine
neurotoxicity
material basis
mechanism of action
target
toxic component
作者简介
第一作者:何海,硕士研究生。研究方向:中药药效物质基础及质量控制。E-mail:hehai1128@126.com;通信作者:邵晶,教授,硕士生导师,博士。研究方向:中药药效物质基础、质量控制及产品开发。E-mail:cn221@163.com。
