摘要
【目的】探讨外周血单核细胞计数与高密度脂蛋白胆固醇浓度比值(MHR)、外周血中性粒细胞计数与淋巴细胞计数比值(NLR)与2型糖尿病(T2DM)内热证的相关性。【方法】收集647例T2DM患者(包括内热证311例和非内热证336例)的临床资料,分析内热证与非内热证患者的肾功能指标与MHR、NLR水平,探讨MHR、NLR与T2DM内热证的相关性。【结果】(1)与非内热证患者相比,内热证患者的尿素氮、血肌酐、尿酸升高,肾小球滤过率(eGFR)下降,差异均有统计学意义(P<0.01)。(2)与非内热证患者相比,内热证患者的MHR、NLR均升高,差异均有统计学意义(P<0.01)。(3)相关性分析结果显示:MHR与血肌酐、尿酸呈正相关,与eGFR呈负相关,差异均有统计学意义(P<0.05);NLR与尿素氮、血肌酐呈正相关,与eGFR呈负相关,差异均有统计学意义(P<0.05)。(4)线性回归分析结果显示:内热证与MHR、NLR呈正相关,内热证是MHR、NLR水平升高的危险因素,随着内热程度的加重,其回归系数逐渐增加,差异均有统计学意义(P<0.05)。【结论】T2DM内热证患者与非内热证患者相比,肾功能更差,MHR、NLR更高;MHR、NLR与早期肾功能损伤密切相关,提示其可能成为预测T2DM早期肾功能损伤的新型标志物;内热证是MHR、NLR水平升高的危险因素之一,可为临床从热论治T2DM提供依据。
Objective To investigate the correlation of mononuclear to high-density lipoprotein cholesterol ratio(MHR)and neutrophil-to-lymphocyte ratio(NLR)in the peripheral blood with type 2 diabetes mellitus(T2DM)of internal-heat syndrome type.Methods The clinical data of 647 patients with T2DM(311 cases of internal heat syndrome and 336 cases of non-internal heat syndrome)were collected,and the renal function indexes as well as the MHR and NLR of patients with internal heat syndrome and non-internal heat syndrome were investigated.And then the correlation of MHR and NLR with T2DM of internal heat syndrome type was explored.Results(1)In comparison with the T2DM patients of non-internal heat syndrome,the levels of blood urea nitrogen(BUN),serum creatinine and uric acid were elevated and estimated glomerular filtration rate(eGFR)was decreased in T2DM patients with internal heat syndrome,and the differences were statistically significant(P<0.01).(2)In comparison with the T2DM patients of non-internal heat syndrome,MHR and NLR were high in patients with internal heat syndrome,and the differences were statistically significant(P<0.01).(3)The results of correlation analysis showed that MHR was positively correlated with serum creatinine and uric acid,and was negatively correlated with eGFR,and the differences were statistically significant(P<0.05).NLR was positively correlated with BUN and serum creatinine,and was negatively correlated with eGFR,and the differences were statistically significant(P<0.05).(4)The results of linear regression analysis showed that the internal heat syndrome was positively correlated with MHR and NLR,internal heat syndrome was a risk factor for the elevated MHR and NLR levels,and the regression coefficient gradually increased with the aggravation of internal heat,the differences being all statistically significant(P<0.05).Conclusion T2DM patients with internal heat syndrome have worse renal function and higher MHR and NLR than the T2DM patients with non-internal heat syndrome.MHR and NLR are closely related to the early renal impairment,suggesting that they may be used as the novel markers to predict early renal impairment in T2DM.Internal heat syndrome is one of the risk factors for elevated MHR and NLR levels,which may provide evidence for clinical treatment of T2DM from the perspective of removing internal heat.
作者
魏蜀吴
姜伟民
张佳乐
薛哲哲
王文娜
仝伶秀
孙卫卫
王晓楠
WEI Shu-Wu;JIANG Wei-Min;ZHANG Jia-Le;XUE Zhe-Zhe;WANG Wen-Na;TONG Ling-Xiu;SUN Wei-Wei;WANG Xiao-Nan(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《广州中医药大学学报》
CAS
2022年第11期2495-2501,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
作者简介
魏蜀吴(1996-),女,硕士研究生,E-mail:806305335@qq.com;通信作者:孙卫卫(1982-),女,主任医师,博士研究生导师,E-mail:sunweitcm@163.com;通信作者:王晓楠(1985-),男,主治医师,E-mail:wxndoctor@163.com。
