摘要
目的评价阳和平喘方辅助治疗肾虚夹痰型COPD急性加重期患者的疗效。方法将符合入选标准的2019年5月-2021年7月海口市中医医院86例COPD急性加重期患者,采用随机数字表法分为2组,每组43例。对照组予以西医常规治疗措施,观察组在对照组基础上服用阳和平喘方。2组均治疗14 d。分别于治疗前后进行中医证候评分,采用ELISA法检测血清CRP、TNF-α、IL-6水平,采用全自动肺功能检测仪检测患者第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)、FEV1占预计值百分比(FEV1%),评价临床疗效。结果观察组总有效率为90.70%(39/43)、对照组为72.09%(31/43),2组比较差异有统计学意义(χ^(2)=4.91,P<0.05)。治疗后,观察组咳嗽咳痰、喘息气短、纳呆食少、汗出肢冷评分及总分均低于对照组(t值分别为10.21、11.30、15.77、13.87、8.73,P值均<0.001),血清CRP、TNF-α、IL-6水平低于对照组(t值分别为22.43、18.21、20.90,P值均<0.001),FEV1/FVC[(62.58±5.23)比(58.47±11.61),t=2.12]、FEV1[(63.79±1.47)比(60.17±10.94),t=2.15]水平高于对照组(P<0.05)。结论阳和平喘方可有效改善COPD急性加重期患者的肺功能,缓解临床临床症状,降低血清CRP、TNF-α、IL-6水平,提高疗效。
Objective To investigate the efficacy of Yanghe Pingchuan Decoction in the treatment of chronic obstructive pulmonary disease(COPD)with syndrome of kidney deficiency and phlegm in the acute exacerbation stage.Methods A total of 86 patients meeting the standard with acute exacerbation of COPD who were admitted to Haikou Hospital of TCM from May 2019 to July 2021 were selected and divided into an observation group and a control group by random number table method,with 43 cases in each group.The patients in the control group were treated with conventional Western medicine,and the patients in the experimental group were treated with Yanghe Pingchuan Decoction on the basis of the treatment in the control group.Both groups took 14 days of treatment.Scoring of TCM symptom of both groups before and after treatment was conducted.The serum levels of CRP,TNF-αand IL-6 were detected by ELISA,and the ratio of forced expiratory volume in 1 second to forced vital capacity(FEV1/FVC)and the percentage of FEV1 to predicted value(FEV1%)were detected by automatic pulmonary function tester.Clinical efficacy was evaluated.Results The observed total effective rate was 90.70%(39/43)in the observation group,which was significantly higher than 72.09%(31/43)in the control group,with statistical significance(χ^(2)=4.91,P<0.05).After treatment,the symptom scores of cough and expectoration,wheezing,shortness of breath,poor appetite,sweating and cold limbs in the observation group were significantly lower than those in the control group(t values were 10.21,11.30,15.77,13.87,8.73,respectively,all Ps<0.01);the levels of CRP and TNF-α,IL-6 in the observation group were significantly lower than those in the control group(t values were 22.43,18.21,20.90,respectively,all Ps<0.01);the levels of FEV1/FVC(62.58±5.23 vs.58.47±11.61,t=2.12),FEV1(63.79±1.47 vs.60.17±10.94,t=2.15)in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Yanghe Pingchuan Decoction can effectively improve the pulmonary function of patients with acute exacerbation of COPD,relieve clinical symptoms,reduce the levels of serum CRP,TNF-αand IL-6,and improve the efficacy.
作者
吴文芳
赖娟
周燕
Wu Wenfang;Lai Juan;Zhou Yan(Department of Internal Medicine,Haikou Hospital of Traditional Chinese Medicine,Haikou 570206,China;Department of Geriatrics,Hainan Traditional Chinese Medicine Hospital,Haikou 570100,China)
出处
《国际中医中药杂志》
2022年第12期1365-1369,共5页
International Journal of Traditional Chinese Medicine
关键词
肺疾病
慢性阻塞性
阳和平喘方
肾虚夹痰证
中西医结合疗法
Pulmonary disease,chronic obstructive
Yanghe Pingchuan Decoction
Kidney deficiency with phlegm syndrome
Integrated Chinese traditional and western medicine therapy
作者简介
通信作者:吴文芳,Email:wuwenfang8604@163.com。
