摘要
目的分析艾司西酞普兰、重复经颅磁刺激联合认知行为疗法对老年抑郁症患者认知行为及炎症因子的影响。方法选取2020年1~12月温州市第七人民医院收治的70例老年抑郁症患者为研究对象,根据随机数字表法将其分为对照组和试验组,每组各35例。对照组患者采用艾司西酞普兰治疗,试验组患者采用艾司西酞普兰+重复经颅磁刺激+认知行为疗法治疗。比较两组患者治疗前后的简易应对方式问卷(simplified coping style questionnaire,SCSQ)、简易精神状态检查量表(mini-mental status examination,MMSE)、社会支持评定量表(social support rating scale,SSRS)、一般自我效能感量表(general self-efficacy scale,GSES)、家庭关怀度指数问卷(family adaption,partnership,growth,affection resolve index,APGAR)评分、巨噬细胞移动抑制因子(macrophage migration inhibition factor,MIF)、脑源性神经营养因子(brain derived neurotrophic factor,BDNF)、皮质醇(cortisol,Cor)、白细胞介素(interleukin,IL)-1β、IL-6、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)等指标。结果治疗后,两组患者的SCSQ、MMSE、SSRS、GSES、APGAR评分及BDNF均显著高于本组治疗前,MIF、Cor、IL-1β、IL-6、TNF-α均显著低于本组治疗前(P<0.05),且试验组患者的SCSQ、MMSE、SSRS、GSES、APGAR及BDNF均显著高于对照组,MIF、Cor、IL-1β、IL-6、TNF-α均显著低于对照组(P<0.05)。结论老年抑郁症患者在常规药物治疗的基础上联合重复经颅磁刺激和认知行为疗法可改善其负面情绪,促进其认知功能恢复,提升社会功能与自我效能。
Objective To analyze the effects of escitalopram,repeated transcranial magnetic stimulation combined with cognitive behavioral therapy on cognitive behavior and inflammatory factors in elderly patients with depression.Methods Seventy elderly patients with depression admitted to the Seventh People’s Hospital of Wenzhou from January to December 2020 were selected as research objects,and were divided into control group and experimental group according to random number table method,with 35 cases in each group.Control group was treated with escitalopram,and experimental group was treated with escitalopram+repeated transcranial magnetic stimulation+cognitive behavioral therapy.The simplified coping style questionnaire(SCSQ),mini-mental status examination(MMSE),social support rating scale(SSRS),general self-efficacy scale(GSES),family adaption,partnership,growth,affection resolve index(APGAR)score and macrophage migration inhibition factor(MIF),brain derived neurotrophic factor(BDNF),cortisol(Cor),interleukin(IL)-1β,IL-6,tumor necrosis factor-α(TNF-α)were compared.Results After treatment,SCSQ,MMSE,SSRS,GSES,APGAR scores and BDNF in two groups were significantly higher than before,while MIF,Cor,IL-1β,IL-6 and TNF-α were significantly lower than before(P<0.05).The SCSQ,MMSE,SSRS,GSES,APGAR scores and BDNF in experimental group were significantly higher than those in control group,while the levels of MIF,Cor,IL-1β,IL-6 and TNF-α in experimental group were significantly lower than those in control group(P<0.05).Conclusion The combination of repeated transcranial magnetic stimulation and cognitive behavioral therapy on the basis of conventional drug therapy can improve the negative emotions of patients with depression,promote the recovery of cognitive function,and improve the social function and self-efficacy of patients.
作者
柯婷婷
宋秀娟
张亮堂
徐银锋
叶鑫武
林翠绿
KE Tingting;SONG Xiujuan;ZHANG Liangtang;XU Yinfeng;YE Xinwu;LIN Cuilv(Department of Geriatrics,the Seventh People’s Hospital of Wenzhou,Wenzhou 325000,Zhejiang,China;Department of Psychiatric,the Seventh People’s Hospital of Wenzhou,Wenzhou 325000,Zhejiang,China)
出处
《中国现代医生》
2023年第1期56-59,共4页
China Modern Doctor
基金
温州市科研项目(Y20190481)。
关键词
老年抑郁症
重复经颅磁刺激
认知行为疗法
认知功能
Geriatric depression
Repeated transcranial magnetic stimulation
Cognitive behavioral therapy
Cognitive function
作者简介
通信作者:柯婷婷,电子信箱:ktingting217@163.com。
