摘要
目的探讨大分割调强放疗(IMRT)对乳腺癌保乳术后患者肿瘤标志物水平及预后的影响。方法选取2017年7月至2018年1月我院接收的86例乳腺癌保乳术后患者作为研究对象,根据随机数字表法将其分为对照组和观察组,各43例。对照组给予常规放疗,观察组给予大分割IMRT。比较两组的治疗效果。结果治疗后,观察组的β_(2)-微球蛋白(β_(2)-MG)、癌胚抗原(CEA)、细胞角蛋白19片段抗原21-1(CYFRA21-1)、甲胎蛋白(AFP)水平均低于对照组(P<0.05)。观察组的不良反应总发生率低于对照组(P<0.05)。随访1年,观察组的复发率低于对照组,局部控制率高于对照组(P<0.05),但两组的生存率无明显差异(P>0.05);随访3年,观察组的复发率低于对照组,局部控制率与生存率高于对照组(P<0.05)。结论大分割IMRT应用于乳腺癌保乳术后患者可调节机体肿瘤标志物水平,降低不良反应发生率,改善预后,值得推广。
Objective To explore the effects of large segment intensity modulated radiation therapy(IMRT) on the tumor markers levels and prognosis of breast cancer patients after breast conserving surgery. Methods A total of 86 patients with breast cancer after breast conserving surgery received in our hospital from July 2017 to January 2018 were selected as the research objects and divided into control group and observation group according to random number table method, with 43 cases in each group. The control group was given conventional radiotherapy, and the observation group was given large segment IMRT. The therapeutic effect of the two groups was compared. Results After treatment, the levels of β_(2)-microglobulin(β_(2)-MG), carcinoembryonic antigen(CEA), serum cytokeratin 19 fragment antigen(CYFRA21-1) and alpha feto protein(AFP) in the observation group were lower than those in the control group(P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05). After 1 year of follow-up, the recurrence rate in the observation group was lower than that in the control group, the local control rate was higher than that in the control group(P<0.05), but there was no significant difference in survival rate between the two groups(P>0.05);after 3 years of follow-up, the recurrence rate in the observation group was lower than that in the control group, and the local control rate and survival rate were higher than those in the control group(P<0.05). Conclusion The large segment IMRT applied in patients with breast cancer after breast conserving surgery can adjust the levels of tumor markers in the body,reduce the incidence of adverse reactions and improve the prognosis, which is worthy of promotion.
作者
赵钦
王虹伊
ZHAO Qin;WANG Hongyi(Xi'an International Medical Center Hospital,Xi'an 710100,China)
出处
《临床医学研究与实践》
2023年第1期32-34,共3页
Clinical Research and Practice
基金
西安国际医学中心医院院级课题项目(No.2021QN019)。
关键词
乳腺癌保乳术
大分割调强放疗
肿瘤标志物
breast conserving surgery for breast cancer
large segment intensity modulated radiation therapy
tumor marker
作者简介
赵钦(1992-),女,住院医师,学士。研究方向:肿瘤放射治疗;通讯作者:王虹伊,E-mail:278422510@qq.com.
