摘要
目的观察早期乳腺癌保乳术后采用大分割调强放疗的近期疗效、不良反应和美容效果。方法2014年6月至2015年3月保乳术后行调强放疗的37例pTis-2N0M0期乳腺癌患者。全乳42.56Gy/16次,瘤床补量10Gy/次,总疗程29d。局部区域控制率和总生存率用Kapian-Meier法计算。结果随访率100%。2年局部区域控制率、生存率均为100%;上肢水肿6例;1、2级放射性肺炎分别为3、2例;美容效果满意率占92%;与同期保乳术后常规分割放疗相比,放疗次数由30次降至21次,疗程由42d缩短至29d,费用由30 375元降至19 575元。结论乳腺癌保乳术后全乳三维调强大分割放疗组患者选择恰当,局部控制、不良反应和美容评价初步结果较好,且能显著降低治疗时间和费用。
Objective To observe the therapeutic effects,cosmetic results,and toxicities of central hypofractionated intensity modulated radiotherapy for patients with early-stage breast cancer after breast-conserving surgery.Methods From June 2014 to March 2015,37 patients with pTis-2N0M0 breast cancer after breast-conserving surgery were enrolled in the trial.Intensity modulated conformal radiotherapy or simplified intensity modulated radiotherapy was applied to each patient.The hypofractionated radiotherapy schedule was 42.56 Gy/16 fractions to the whole breast.With a boost of 10 Gy/5 fractions to the tumor bed.The total course of treatment was 29 days.Locoregional control and overall survival were calculated by Kaplan-Meier method.Results The follow-up rate was 100%.The 2-year local regional control and overall survival were both 100%,and 6 developed grade 2 upper extremity edema,3 developed grade 1 radiation pneumonitis,and 2 developed grade 2 radiation pneumonitis.Compared with the conventional fractionated radiotherapy for the patients with early-stage breast cancer after breast-conserving surgery,the hypofractionated intensity modulated radiotherapy had the number of fractions radiotherapy decreased from 30 to 21.Course of treatment shortened from 42 days to 29 days.and the cost cut from￥30 375 to￥19 575.Conclusion The central hypofractionated intensity modulated radiotherapy for the patients with early-stage breast cancer after breast-conserving surgery have good therapeutic effects and cosmetic results and acceptable toxicities,and it as well significantly reduced time and cost of treatment.
作者
王义海
曹茜
贺春钰
木妮热·木沙江
Wang Yihai;Cao Qian;He Chunyu;Munnire·Mshajiang(Department of Radiation Oncology,the Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830011,China)
出处
《山西医药杂志》
CAS
2018年第1期7-9,共3页
Shanxi Medical Journal
基金
新疆维吾尔自治区自然科学基金(2017D01-C378)
新疆医科大学创新基金(XYDCX2015)
关键词
乳腺肿瘤
外科学
保乳术
乳腺肿瘤/放射疗法
放射疗法
大分割放疗
Breast neoplasms
Surgery,breast-conserving surgery
Breast neoplasms/radiotherapy
Radiotherapy,hypofractionation
作者简介
通信作者：木妮热·木沙江,Email:muni6@aliyun.com
