摘要
目的运用网状meta分析比较多种方案治疗寒热错杂型溃疡性结肠炎(UC)的效果差异。方法计算机检索中国知网、万方数据库、维普网、PubMed、Embase和Web of Science,搜集各种治疗寒热错杂型UC的随机对照试验(RCT)。采用Stata 15.0软件和R 3.6.1软件的gemtc软件包对纳入分析文献的临床总有效率进行网状meta分析。结果共纳入33个RCT,涉及2263例患者,包括8种方案[A方案(中药口服)、B方案(中药口服+中药灌肠)、C方案(中药口服+西药口服)、D方案(中药口服+西药口服+中药灌肠)、a方案(西药口服)、b方案(西药口服+西药灌肠)、d方案(西药口服+中药灌肠)、e方案(中药灌肠)]。8种方案临床总有效率比较的网状meta分析结果显示,B方案高于a方案(OR=9.12,95%CI:2.38~42.82)、b方案(OR=2.64,95%CI:1.11~6.61)、d方案(OR=2.85,95%CI:1.20~7.03)、e方案(OR=10.32,95%CI:1.68~81.73),A方案(OR=2.46,95%CI:1.30~4.18)、C方案(OR=4.80,95%CI:3.22~7.31)、D方案(OR=3.71,95%CI:1.21~13.18)均高于a方案,C方案高于A方案(OR=0.52,95%CI:0.24~0.98),差异有统计学意义(P<0.05)。各方案的排序概率由大到小排序为:B方案>C方案>D方案>d方案>A方案>b方案>a方案>e方案。结论中医药及中西医结合方案治疗寒热错杂性UC效果均优于西医方案,其中中药口服联合中药灌肠可能是临床治疗寒热错杂型UC的最佳方案。
Objective To compare the efficacy of multiple regimens for ulcerative colitis(UC)with syndrome of intermingled heat and cold by mesh meta-analysis.Methods Randomized controlled trials(RCT)on intervention in the treatment of UC with syndrome of intermingled heat and cold were collected by searching CNKI,Wanfang Data,VIP,PubMed,Embase,and Web of Science.The clinical total effective rate of the included literatures was analyzed by Stata 15.0 and gemtc software package of R 3.6.1.Results A total of 33 RCTs were included,involving 2263 patients.It includes eight schemes(scheme A[oral Chinese medicine],scheme B[oral Chinese medicine+Chinese medicine enema],scheme C[oral Chinese medicine+western medicine],scheme D[oral Chinese medicine+western medicine+Chinese medicine enema],scheme a[oral western medicine+western medicine enema],scheme b[oral western medicine+western medicine enema],scheme d[oral western medicine+Chinese medicine enema],and scheme e[Chinese medicine enema]).The results of mesh meta-analysis comparing the clinical total effective rate of eight schemes showed that scheme B was higher than scheme a[OR=9.12,95%CI:2.38-42.82],scheme b[OR=2.64,95%CI:1.11-6.61],scheme d[OR=2.85,95%CI:1.20-7.03],and scheme e[OR=10.32,95%CI:1.68-81.73],scheme A[OR=2.46,95%CI:1.30-4.18],scheme C[OR=4.80,95%CI:3.22-7.31],scheme D[OR=3.71,95%CI:1.21-13.18]were higher than those of scheme a,and scheme C was higher than scheme A[OR=0.52,95%CI:0.24-0.98],the differences were statistically significant(P<0.05).The ranking probability of each scheme in descending order is as follows: scheme B>scheme C>scheme D>scheme d>scheme A>scheme b>scheme a>scheme e. Conclusion The efficacy of Chinese medicine and the integration of traditional and western medicine in the treatment of UC with syndrome of intermingled heat and cold is better than that of western medicine, and oral Chinese medicine combined with Chinese medicine enema may be the best clinical treatment of UC with syndrome of intermingled heat and cold.
作者
刘深梵
宫宇澄
寇梦佳
王志斌
LIU Shenfan;GONG Yucheng;KOU Mengjia;WANG Zhibin(The Second Clinical School of Medicine,Beijing University of Chinese Medicine,Beijing100078,China;Department of Spleen,Stomach,and Hepatobiliary,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing100078,China)
出处
《中国医药导报》
CAS
2022年第35期110-115,共6页
China Medical Herald
基金
国家重点研发计划(中医药现代化研究)项目(2017YFC1700104)
北京中医药大学重点攻关项目(2020-JYB-ZDGG-134)。
关键词
溃疡性结肠炎
中医药
中西医结合
西医
随机对照试验
网状meta
Ulcerative colitis
Traditional Chinese medicine
Integration of traditional and western medicine
Western medicine
Randomized controlled trial
Mesh meta-analysis
作者简介
刘深梵(1998.2-),女,北京中医药大学第二临床医学院2020级中医内科学在读硕士研究生。研究方向:中西医结合治疗脾胃肝胆疾病;通讯作者:王志斌(1978.3-),男,博士,主任医师。研究方向:中西医结合治疗脾胃肝胆疾病。
