摘要
目的:探讨黄芪益肾化浊汤联合达格列净治疗糖尿病肾病的临床效果。方法:选取100例糖尿病肾病患者,随机分为观察组与对照组,每组50例。对照组采用达格列净治疗,观察组在对照组基础上加用黄芪益肾化浊汤治疗。比较两组的临床疗效、糖脂代谢指标、肾功能指标及不良反应。结果:观察组治疗总有效率为92.00%,高于对照组74.00%,差异有统计学意义(P<0.05);其中观察组糖代谢指标FPG、HbAlc、2hPG水平低于对照组(P<0.05),糖脂代谢指标TG、TC、LDL-C水平低于对照组(P<0.05),肾功能指标β2-MG、BUN、Scr、UmAlb/UCr水平低于对照组(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论:黄芪益肾化浊汤联合达格列净可提高治疗糖尿病肾病的效果,改善肾功能。
Objective: To investigate the clinical effects of Huangqi Yishen Huazhuo decoction combined with dapagliflozin on patients with diabetes nephropathy. Methods: 100 patients with diabetes nephropathy were randomized into the observation group and control group, each with 50 cases. The control group were treated with dapagliflozin, while the observation group were treated with Huangqi Yishen Huazhuo decoction on the basis of the treatment for the control group. The clinical efficacy, glycolipid metabolism index, renal function index and adverse reactions of the two groups were compared. Results: The total effective rate was 92.00% in the observation group, higher than 74.00% in the control group, and the differences were statistically significant(P<0.05);levels of FPG, HbAlc and 2 hPG were lower than those of the control group(P<0.05);levels of TG, TC, LDL-C were lower than those of the control group(P<0.05);β2-mg, BUN,Scr and UmAlb/UCr of the observation group were lower than those of the control group(P<0.05);and there was no statistical difference of adverse reactions between both groups(P>0.05). Conclusion: Huangqi Yishen Huazhuo decoction combined with dapagliflozin has significant therapeutic effect on patients with diabetes nephropathy, which can improve the renal functions of patients.
作者
刘全红
LIU Quanhong(Guilin Hospital of Integrated Traditional Chinese and Western Medicine,Guilin 541001,China)
出处
《华夏医学》
CAS
2022年第5期102-106,共5页
Acta Medicinae Sinica
关键词
糖尿病肾病
达格列净
黄芪益肾化浊汤
糖脂代谢
肾功能
diabetes nephropathy
dapagliflozin
Huangqi Yishen Huazhuo decoction
glucolipid metabolism
renal function
