摘要
目的了解高通量透析(HFHD)联合Supra-HFR血滤吸附对维持性血液透析患者甲状旁腺素(PTH)、β2-微球蛋白(β2-MG)的清除效果。方法60例维持性血液透析患者随机采用HFHD(HFHD组)、血液透析联合Supra-HFR(HD+HFR组)和HFHD联合Supra-HFR(HFHD+HFR组)治疗6个月,比较3组患者治疗前后PTH、β2-MG、C反应蛋白(CRP)水平及临床症状(体力、食欲、睡眠、皮肤瘙痒)变化。结果3组患者治疗后PTH、β2-MG、CRP水平及临床症状评分显著降低,其中HFHD+HFR组更明显(P<0.05或0.01)。结论HFHD联合Supra-HFR可提高维持性血液透析患者PTH、β2-MG、CRP清除效果,减轻临床症状。
Objective To observe the effect of high-flux hemodialysis(HFHD)and Supra-HFR on parathyroid hormone(PTH)andβ2-microglobulin(β2-MG)removal in maintenance hemodialysis(MHD)patients.Methods Sixty MHD patients were randomly treated with HFHD(HFHD group),hemodialysis plus Supra-HFR(HD+HFR group),or HFHD plus Supra-HFR(HFHD+HFR group)for 6 months.Levels of PTH,β2-MG and C-reactive protein(CRP),and clinical symptoms(physical strength,appetite,sleep,pruritus)were compared among 3 groups before and after treatment.Results Levels of PTH,β2-MG and CRP,and symptom scores were decreased in 3 groups posttreatment, especially in HFHD+HFR group (P<0.01 or 0.05). Conclusion HFHD plus Supra-HFR can improve the removal of PTH, β2-MG and CRP, and alleviate clinical symptoms in MHD patients.
作者
冯艳翠
余柏林
张海红
FENG Yan-cui;YU Bai-lin;ZHANG Hai-hong(Department of Nephrology,Kaiping Central Hospital,Kaiping 529300,China)
出处
《广东医科大学学报》
2022年第6期687-690,共4页
Journal of Guangdong Medical University
基金
江门市医疗卫生科技计划项目(2021YL10006)。
作者简介
冯艳翠(1982-),女,本科,副主任医师,E-mail:yancuif@21cn.com。
