摘要
目的比较急、慢性荨麻疹患者的尘螨组合特异性IgE(sIgE)检测结果,分析尘螨在两种疾病中的分布情况,探讨尘螨阳性的慢性荨麻疹患者是否可以纳入尘螨特异性免疫治疗的范畴。方法回顾性选取2020年1月至2021年6月就诊于厦门大学附属中山医院的417例病例,其中正常人群组164例,急性荨麻疹组105例,慢性荨麻疹组148例。应用免疫印迹法检测过敏原sIgE,比较各组的尘螨阳性率、阳性结果总体水平等参数。结果急、慢性荨麻疹组的尘螨组合、蟑螂sIgE阳性率均高于正常人群组,差异有统计学意义(P<0.017);但急、慢性荨麻疹组尘螨组合、蟑螂sIgE阳性率比较,差异无统计学意义(P>0.05);急、慢性荨麻疹组的尘螨组合sIgE阳性结果总体水平、2级及以上的阳性率比较,差异均无统计学意义(P>0.05)。结论尘螨在急、慢性荨麻疹患者致敏中差异无统计学意义,尘螨并非导致荨麻疹反复的促进因素,目前无足够理论证据支持慢性荨麻疹行尘螨特异性免疫治疗。
Objective To compare the detection results of dust mite specific IgE(sIgE)in patients with acute and chronic urticaria,to analyze the distribution of dust mites in the two diseases,and to explore whether dust mite positive patients with chronic urticaria can be included in the category of dust mite specific immunotherapy.Methods A total of 417 cases from January 2020 to June 2021 in Zhongshan Hospital Xiamen University were retrospectively selected,included 164 cases of normal subjects,105 cases of acute urticaria patients and 148 cases of chronic urticaria patients.The allergen sIgE was detected by Western blotting,and the positive rate of dust mites,and the overall level of positive results in each group were compared.Results The sIgE positive rate of dust mite combination and cockroach in the acute and chronic urticaria groups were higher than those in the normal population group,and the differences were statistically significant(P<0.017).However,there were no significant difference between the acute and chronic urticaria groups in the sIgE positive rate of dust mite combination and cockroach(P>0.05).There were no statistically significant difference between the acute and chronic urticaria groups in the overall level of sIgE positive results of dust mite combination and the positive rate of grade 2 and above(P>0.05).Conclusion There is no significant difference in the sensitization of acute urticaria and chronic urticaria.Dust mite is not a contributing factor to the recurrence of urticaria.There is not enough theoretical evidence to support the use of dust mite specific immunotherapy for chronic urticaria.
作者
林辰曦
杨羡球
汤颖
肖芸
LIN Chenxi;YANG Xianqiu;TANG Ying;XIAO Yun(Department of Pediatrics,Zhongshan Hospital Xiamen University,Fujian Province,Xiamen361000,China;Department of Clinical Laboratory,Zhongshan Hospital Xiamen University,Fujian Province,Xiamen361000,China)
出处
《中国当代医药》
CAS
2022年第34期76-79,共4页
China Modern Medicine
作者简介
林辰曦(1984-),女,硕士,研究方向:儿内科呼吸专业。
