摘要
目的探讨自血疗法联合苯海拉明治疗慢性荨麻疹的疗效及其对血清免疫球蛋白E(Ig E)、白介素4(IL-4)、补体与Th1/Th2相关细胞因子水平的影响。方法将入选的80例慢性荨麻疹患者随机分为2组,治疗组40例给予自血疗法联合苯海拉明肌注以及口服氯雷他定治疗,对照组40例仅给予苯海拉明肌注以及口服氯雷他定治疗,均以30 d为1个疗程。疗程结束后,观察两组临床疗效及血清Ig E、补体(C3、C4)、Th1/Th2相关细胞因子水平[γ-干扰素(IFN-γ)、IL-4、白介素18(IL-18)、白介素10(IL-10)]变化。结果治疗组1例脱落,对照组3例脱落。治疗30 d后,两组患者临床疗效比较,差异无统计学意义(P>0.05);停药90 d后,治疗组治疗有效率为84.62%,高于对照组62.16%,差异有统计学意义(P<0.05)。治疗组血清Ig E水平低于对照组,C3、C4水平高于对照组,差异有统计学意义(P<0.05);治疗组IL-4、IL-10水平低于对照组,IL-18、IFN-γ水平高于对照组,差异有统计学意义(P<0.05)。结论自血疗法联合苯海拉明治疗慢性荨麻疹,可提高临床远期疗效,机制可能与降低Ig E水平、提升补体C3、C4水平、改善免疫功能有关。
Objective To investigate the efficacy of autohemotherapy combined with diphenhydramine for chronic urticaria and the impacts of this combined therapy on levels of serum immunoglobulin E(IgE),interleukin 4(IL-4),complement and Th1/Th2 associated cytokines.Methods 80 patients with chronic urticaria were ran-domly divided into two groups.40 patients in the study group received autohemotherapy combined with intramuscu-lar injections of diphenhydramine and oral administration of loratadine,while 40 patients in the control group only received intramuscular injections of diphenhydramine and oral administration of loratadine.30 days was one course of treatment.The clinical efficacy and changes of serum IgE,complements(C3,C4)and Th1/Th2 related cytokines including interferon gamma(IFN-γ),interleukin 4(IL-4),interleukin 18(IL-18),and interleukin 10(IL-10)in the two groups were observed after treatment.Results During the period of follow-up,one patient was lost in the study group while three in the control group.The efficacy did not differ statistically between the two groups 30 days after treatment(P>0.05).The effectiveness rate was higher in the study group than in the control group(84.62%vs.62.16%)90 days after medicine termination(P<0.05).Level of serum IgE was lower while levels of C3 and C4 were higher in the study group than in the control group(P<0.05).Levels of IL-4 and IL-10 were lower while levels of IL-18 and IFN-γwere higher in the study group than in the control group(P<0.05).Conclusions Autohemotherapy combined with diphenhydramine for chronic urticaria can improve the clinical long-term efficacy,whose mechanism may be related to a decrease in IgE level,an increase in complements C3 and C4 levels and improvement of immune function.
作者
陈耿明
黄国强
王锦云
CHEN Gengming;HUANG Guoqiang;WANG Jinyun(Depart-ment of Dermatology and Venereology,People′s Hospital of Jieyang,Jieyang 522010,China)
出处
《实用医学杂志》
CAS
北大核心
2018年第13期2209-2212,共4页
The Journal of Practical Medicine
基金
揭阳市医学科学技术研究立项项目(编号:201613)
关键词
慢性荨麻疹
自血疗法
苯海拉明
chronic urticaria
autohemotherapy
diphenhydramine
