摘要
细胞周期基因异常表达是肿瘤细胞携带缺陷基因无限增殖的关键,是具有巨大潜力的临床治疗靶点。中药活性成分因其抗癌效果显著,不良反应少等优点而被广泛关注。研究显示有中药活性成分可调控Cyclin、CDK和CKI等基因表达,而抑制肿瘤细胞生长,诱导细胞凋亡。本研究旨在为中药活性成分抗癌治疗的进一步临床应用提供药效基因分子生物学基础。
The abnormal expressions of cell genes are the key gene group for tumor cells carrying defective genes for unlimited proliferation,and they are the clinical targets with great potential.The active components of traditional Chinese medicine are widely concerned because of their remarkable anticancer effect and few adverse reactions.It has been shown that the active components of traditional Chinese medicine can regulate the expressions of Cyclin,CDK and CKI,and inhibit the growth of tumor cells and induce apoptosis.In-depth research can provide molecular biological basis of pharmacodynamic genes for anticancer treatment with traditional Chinese medicine and further clinical application of the active components.
作者
申倩
沈雨蕾
曾雪倩
李俊辰
张建岭
庞博
SHEN Qian;SHEN Yulei;ZENG Xueqian;LI Junchen;ZHANG Jianling;PANG Bo(Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Traditional Chinese Medicine,Beijing 100029,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《天津中医药大学学报》
CAS
2022年第6期806-811,共6页
Journal of Tianjin University of Traditional Chinese Medicine
关键词
中药
活性成分
肿瘤
细胞周期
基因调控
traditional Chinese medicine
active component
tumor
cell cycle
gene regulation
作者简介
申倩(1999-),女,硕士研究生在读,研究方向为肿瘤中医药防治与名老中医经验传承方法学;通讯作者:张建岭,E-mail:jianlingzhang@tjutcm.edu.cn;通讯作者:庞博,E-mail:drpangbo@gmail.com。
