摘要
近年来,中医药治疗AD得到广泛关注。中药调控AD的信号通路研究主要集中在脑源性神经营养因子(BDNF)/酪氨酸激酶B(TrkB)通路、PI3K/Akt通路、MAPK通路、蛋白激酶A(PKA)/cAMP应答元件结合蛋白(CREB)通路、NF-κB通路及Wnt通路这6条通路。
In recent years,Traditional Chinese Medicine(TCM)treatment for Alzheimer's disease has been widely concerned.At present,there are more studies on the following 6 pathways:brain-derived neurotrophic factor(BDNF)/tyrosine kinase B(TrkB)signaling pathway,phosphatidy linositol-3-kinases(PI3K)/protein kinase B(Akt)signaling pathway,mitogen-activated protein kinase(MAPK)signaling pathway,protein kinase A(PKA)/cAMP response Element binding protein(CREB)signaling pathway,nuclear factor-κB(NF-κB)signaling pathway,Wnt signaling pathway.
作者
周晓洁
王琪
闫博文
周妍妍
Zhou Xiaojie;Wang Qi;Yan Bowen;Zhou Yanyan(Master Degree Student of Grade 2020,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Basic Medical College of Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《国际中医中药杂志》
2022年第10期1196-1200,共5页
International Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81774197)
黑龙江中医药大学科研基金面上项目(2019ms31)。
关键词
阿尔茨海默病
中医药
信号通路
作用机制
综述
Alzheimer disease
Traditional Chinese Medicine
Signaling pathway
Mechanism of action
Review
作者简介
通信作者:周妍妍,Email:13339319259@163.com;周晓洁,黑龙江中医药大学2020级硕士研究生。
