摘要
骨关节炎(OA)是关节软骨慢性退行性疾病。许多研究表明间充质干细胞(MSCs)可以促进OA的软骨组织修复、改善关节环境等作用。一些MSCs和软骨细胞的共培养实验表明,MSCs可能是通过分泌一些细胞因子发挥作用的,而细胞因子是外泌体(EXs)的重要成分。体外实验证实,间充质干细胞来源的外泌体(MSCs-EXs)与MSCs都具有促进软骨细胞增殖、维持软骨细胞表型、抑制软骨细胞凋亡、促进软骨细胞外基质合成、促进软骨细胞迁移的作用。体内实验也表明,MSCs-EXs在OA中,具有修复软骨、促进软骨基质合成、抑制炎细胞浸润的作用。单纯MSCs-EXs治疗和MSCs治疗相比,具有安全、低成本的优点。这为OA的治疗提供了新的策略。但MSCs-EXs治疗OA的机制尚不明确,本文就MSCs-EXs在OA治疗中的研究进展作一综述。
Osteoarthritis(OA)is a chronic degenerative disease of articular cartilage.Many studies have shown that mesenchymal stem cells can promote the repair of cartilage tissue of OA and improve the joint environment.Some co-cultivation experiments of mesenchymal stem cells and chondrocytes indicate that mesenchymal stem cells may act by secreting some cytokines,and exosomes are an important component of these factors.In vitro experiments confirmed that both exosomes and mesenchymal stem cells derived from mesenchymal stem cells can promote chondrocyte proliferation,maintain chondrocyte phenotype,inhibit chondrocyte apoptosis,promote cartilage extracellular matrix synthesis,and promote chondrocyte migration.In vivo experiments have also shown that exosomes derived from mesenchymal stem cells in OA can repair cartilage,promote cartilage matrix synthesis,and inhibit inflammatory cell infiltration.Compared with mesenchymal stem cell therapy,exosomal therapy alone has the advantages of safety and low cost.This provides a new strategy for the treatment of OA.However,the mechanism of MSCs-EXs in the treatment of osteoarthritis is not clear.This article reviewed the research progress of MSCs-EXs in the treatment of OA.
作者
傅子财
黄勇
陈斐
刘澍雨
朱伟民
Fu Zicai;Huang Yong;Chen Fei;Liu Shuyu;Zhu Weimin(Department of Sports Medicine,Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center,Shenzhen 518035,China)
出处
《中华关节外科杂志（电子版）》
CAS
CSCD
2022年第2期196-201,共6页
Chinese Journal of Joint Surgery(Electronic Edition)
基金
国家自然科学基金(81672234)。
作者简介
通信作者:朱伟民,szhzwm@email.szu.edu.cn。
