摘要
目的探究超早期小骨窗微创颅内血肿清除术治疗高血压脑出血的临床效果。方法选取2017年1月至2020年12月我院收治的60例高血压脑出血患者作为研究对象,根据抽签法将其分为对照组和观察组,各30例。对照组采用常规小骨窗微创颅内血肿清除术,观察组采用超早期小骨窗微创颅内血肿清除术。比较两组的治疗效果。结果两组的治疗总有效率比较,差异无统计学意义(P>0.05)。两组的并发症总发生率比较,差异无统计学意义(P>0.05)。术后3 d,观察组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)水平低于对照组(P<0.05)。术后3 d,观察组的血管生成素-1(Ang-1)、血管内皮生长因子(VEGF)、神经元特异性烯醇化酶(NSE)水平低于对照组,脑源性神经营养因子(BDNF)水平高于对照组(P<0.05)。术后2周,观察组的Fugl-Meyer运动量表(FMA)、Barthel指数(BI)评分高于对照组(P<0.05)。结论超早期小骨窗微创颅内血肿清除术治疗高血压脑出血的效果显著,有利于减轻炎症反应,促进机体恢复,值得推广。
Objective To explore the clinical effect of ultra-early period minimally invasive intracranial hematoma removal with small bone window in the treatment of hypertensive cerebral hemorrhage.Methods A total of 60 patients with hypertensive cerebral hemorrhage admitted in our hospital from January 2017 to December 2020 were selected as the research objects and divided into control group and observation group according to the lottery method,with 30 cases in each group.The control group was treated with conventional minimally invasive intracranial hematoma removal with small bone window,and the observation group was treated with ultra-early period minimally invasive intracranial hematoma removal with small bone window.The therapeutic effects of the two groups were compared.Results There was no significant difference in the total effective rate of treatment between the two groups(P>0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).At 3 d after operation,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high sensitivity C-reactive protein(hs-CRP)in the observation group were lower than those in the control group(P<0.05).At 3 d after operation,the levels of angiopoietin-1(Ang-1),vascular endothelial growth factor(VEGF)and neuron specific enolase(NSE)in the observation group were lower than those in the control group,and the level of brain-drived neurotrophic factor(BDNF)was higher than that of the control group(P<0.05).Two weeks after operation,the scores of Fugl-Meyer Assessment(FMA)and Barthel Index(BI)in the observation group were higher than those in the control group(P<0.05).Conclusion Ultra-early period minimally invasive intracranial hematoma removal with small bone window in the treatment of hypertensive cerebral hemorrhage has a significant effect,it is beneficial to relieve inflammatory reaction,and promote body recovery,which is worthy of promotion.
作者
宋歌
杨治国
SONG Ge;YANG Zhiguo(Hanzhong People's Hospital,Hanzhong 723000,China)
出处
《临床医学研究与实践》
2022年第31期82-85,共4页
Clinical Research and Practice
关键词
高血压脑出血
超早期
小骨窗微创颅内血肿清除术
炎症指标
hypertensive cerebral hemorrhage
ultra-early period
minimally invasive intracranial hematoma removal with small bone window
inflammatory index
作者简介
宋歌(1975-),男,副主任医师,学士。研究方向:神经外科临床;通讯作者:杨治国,E-mail:yzg18191686275@163.com.
