摘要
目的系统评价真武汤合血府逐瘀汤治疗慢性心力衰竭的有效性及安全性。方法计算机检索中国知网(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学文献数据库(SinoMed)、PubMed等数据库中真武汤合血府逐瘀汤治疗慢性心力衰竭的随机对照试验,并提取资料用Jadad评分量表对文献进行质量评价,采用RevMan 5.3进行Meta分析。共纳入17项研究,1483例患者。Meta分析显示结果,治疗后试验组患者的总有效率明显高于对照组,差异有统计学意义[OR=4.56,90%CI(3.25,6.39),Z=8.76,P<0.00001];治疗后试验组患者的中医证候疗效明显高于对照组,差异有统计学意义[OR=3.24,90%CI(1.71,6.14),Z=3.61,P=0.0003];治疗后试验组患者的射血分数明显高于对照组,差异有统计学意义[MD=7.52,95%CI(5.60,9.44),Z=7.68,P<0.00001];治疗后试验组患者的左心室舒张末期内径明显低于对照组,差异有统计学意义[MD=-2.33,95%CI(-2.44,-2.21),Z=39.36,P<0.00001];治疗后试验组患者的左心室收缩末期内径明显低于对照组,差异有统计学意义[MD=-7.59,95%CI(-9.95,-5.23),Z=6.31,P<0.00001];治疗后试验组患者的B型脑钠肽明显低于对照组,差异有统计学意义[MD=-22.29,95%CI(-35.34,-9.24),Z=3.35,P=0.0008];治疗后试验组患者的N末端B型脑钠肽前体明显低于对照组,差异有统计学意义[SMD=-1.93,95%CI(-3.00,-0.86),Z=3.54,P=0.0004]。结论真武汤合血府逐瘀汤在常规西药治疗基础上治疗慢性心力衰竭疗效优于单纯应用西药治疗。
Objective To systematically evaluate the efficacy and safety of Zhenwu Decoction combined with Xuefuzhuyu Decoction in the treatment of chronic heart failure.Methods The randomized controlled trials of Zhenwu Decoction combined with Xuefuzhuyu Decoction in the treatment of chronic heart failure from CNKI,Wanfang,VIP,Sinomed,PubMed and other databases were searched by computer.The Jadad scoring scale was used to evaluate the quality of the literature,and RevMan5.3 was used for Meta-analysis.Results A total of 17 studies involving 1,483 patients were included.Meta-analysis showed that the total effective rate in the experimental group was significantly higher than that in the control group after treatment,the difference was statistically significant[OR=4.56,90%CI(3.25,6.39),Z=8.76,P<0.00001].After treatment,the TCM syndrome effective rate in the experimental group was significantly higher than that in the control group,the difference was statistically significant[OR=3.24,90%CI(1.71,6.14),Z=3.61,P=0.0003].After treatment,the ejection fraction in the experimental group was significantly higher than that in the control group,the difference was statistically significant[MD=7.52,95%CI(5.60,9.44),Z=7.68,P<0.00001].After treatment,the end-diastolic diameter of the left ventricle in the experimental group was significantly lower than that in the control group,and the difference was statistically significant[MD=-2.33,95%CI(-2.44,-2.21),Z=39.36,P<0.00001].After treatment,the systolic diameter of the left ventricle in the experimental group was significantly lower than that in the control group,the difference was statistically significant[MD=-7.59,95%CI(-9.95,-5.23),Z=6.31,P<0.00001].After treatment,B-type natriuretic peptide levels in the experimental group were significantly lower than those in the control group,and the difference was statistically significant[MD=-22.29,95%CI(-35.34,-9.24),Z=3.35,P=0.0008].After treatment,N-terminal B-type natriuretic peptide level in the experimental group was significantly lower than that in the control group,and the difference was statistically significant[SMD=-1.93,95%CI(-3.00,-0.86),Z=3.54,P=0.0004].Conclusion Zhenwu Decoction combined with Xuefuzhuyu Decoction on the basis of conventional western medicine treatment in the treatment of chronic heart failure is better than the use of western medicine alone.
作者
王铭
王秀萍
徐建虎
WANG Ming;WANG Xiu-ping;XU Jian-hu(Ningxia Medical University,Ningxia Regional Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Regional High Incidence Disease,Yinchuan 750004,China;不详)
出处
《中国处方药》
2022年第10期3-7,共5页
Journal of China Prescription Drug
关键词
真武汤合血府逐瘀汤
慢性心力衰竭
META分析
Zhenwu Decoction combined with Xuefuzhuyu Decoction
Chronic heart failure
Meta-analysis
作者简介
通信作者:徐建虎,Email:xjh98@qq.com。
