摘要
目的 分析肺癌病人CT图像特征与Ki-67、高尔基磷酸化蛋白3(GOLPH3)表达的相关性。方法 2019年1月~2021年4月收治的肺癌病人120例。对病人进行CT扫描,收集影像学特征指标(肿瘤直径、位置、毛刺征象、深分叶征象及坏死空洞),免疫组织化学检测肺癌组织中Ki-67、GOLPH3的表达情况,分析CT图像特征与Ki-67、GOLPH3之间的关系。结果 120例肺癌病人中,病灶直径> 3 cm76例(63.33%),周围型肺癌61例(50.83%),无坏死空洞84例(70.00%),无毛刺征象71例(59.17%),有深分叶征象79例(65.83%);Ki-67阳性率为88.33%(106/120),GOLPH3阳性率为79.17%(95/120);Ki-67、GOLPH3在肺癌组织中的表达呈正相关(r=0.381,0.271,P=0.000,0.018);坏死空洞、毛刺征象、深分叶征象与肺癌Ki-67和GOLPH3表达有关(P<0.05);Ki-67、GOLPH3表达在4种病理类型间比较差异有统计学意义(P<0.05),在肺癌的病理分级Ⅲ中的表达高于Ⅰ~Ⅱ级中的表达,差异有统计学意义(P<0.05)。结论 肺癌CT图像特征与Ki-67、GOLPH3阳性表达有相关性,可用于评估肿瘤的增殖能力及预测预后。
Objective To analyze the correlation between CT signs and the expression of Ki-67,golgi phosphoprotein 3(GOLPH3) in patients with lung cancer.Methods 120 patients with lung cancer admitted tofrom January 2019 to April 2021 were selected.They were examined by CT.The CT signs(tumor diameter, location, burr sign, deep lobulation sign and necrotic cavity) were collected.The expression of Ki-67,GOLPH3 in lung cancer tissue was detected by immunohistochemistry, and the correlation between CT signs and the expression of Ki-67,GOLPH3 was analyzed.Results Among the 120 cases of lung cancer, 76 cases(63.33%) had lesion diameter > 3 cm, 61 cases(50.83%) had peripheral lung cancer, 84 cases(70.00%) had no necrotic cavity, 71 cases(59.17%) had no burr sign, 79 cases(65.83%) had deep lobulation sign.The positive rate of Ki-67 was 88.33%(106/120) and the positive rate of GOLPH3 was 79.17%(95/120).The expression of Ki-67,GOLPH3 in lung cancer tissues was positively correlated(r=0.381,0.271,P=0.000,0.018).The expression of Ki-67 and GOLPH3 in lung cancer was correlated with cavity, burr and deep lobulation.The expression of Ki-67 and GOLPH3 were significantly different among the four pathological types(P<0.05).The expression of Ki-67 and GOLPH3 in the pathological grade Ⅲ~Ⅳ were significantly higher than that in gradeⅠ~Ⅱ(P<0.05).Conclusion There is a correlation between CT image features and Ki-67,GOLPH3 positive expression in lung cancer, which can provide reliable basis for evaluating tumor proliferation and predicting prognosis.
作者
侯海文
李菊慧
唐孝武
HOU Haiwen;LI Juhui;TANG Xiaowu(Department of Medical Imaging Center,Chenzhou First People's Hospital,Hunan,Chenzhou 423000,China)
出处
《临床外科杂志》
2022年第8期735-739,共5页
Journal of Clinical Surgery
作者简介
通信作者:侯海文,Email:15096107574@163.com。
