摘要
动脉粥样硬化(AS)是常见的心血管疾病。建立一种与人类病变相似的动物模型是研究防治AS的药物和了解AS的复杂性及机制的主要工具。一般来说,AS动物模型通过高脂饮食引起的血脂代谢异常、斑块形成,再引入诱发血管钙化、诱导免疫炎症、机械损伤动脉或改造相关基因等手段来构建。常选用的动物有大鼠、小鼠、豚鼠、家兔和小型猪。不同的AS动物模型在建模方法、动物模型和周期方面各有特点。本文阐述和比较了AS研究中常用动物模型及其特点,为AS的研究提供参考。
Atherosclerosis(AS)is a common cardiovascular disease.The establishment of an animal model similar to human pathological changes is the major tool for studying the prevention and treatment of AS and understanding the complexity and mechanisms of AS.In general,the AS animal models are based on the abnormal lipid metabolism and plaque formation induced by high-fat diet,and is constructed by means of inducing vascular calcification,immune inflammation,mechanical injury of arteries or modification of related genes.Rats,mice,Guinea pigs,rabbits and miniature pigs are often used.Different animal models of AS have their characteristics in the aspects of modeling method,animal model and cycle.This paper elaborates and compares the animal models commonly used in the AS study and their characteristics in order to provide references for the AS research.
作者
杨定法
赵庆宇婧(综述)
颜红娇
赵声兰(审校)
YANG Dingfa;ZHAO Qingyujing;YAN Hongjiao;ZHAO Shenglan(Yunnan University of Traditional Chinese Medicine,Kunming,Yunnan 650500,China;Technic Center of Kunming Custom,Kunming,Yunnan 650100,China)
出处
《重庆医学》
CAS
2022年第16期2860-2865,共6页
Chongqing medicine
基金
国家自然科学基金项目(81760735)
云南省重大科技专项(202002AA1000055,202102AE090031-3)
云南省科技厅-云南中医药大学联合专项重点项目(2019FF002-006)。
关键词
动脉粥样硬化
造模方法
实验动物
综述
atherosclerosis
modeling method
experimental animal
review
作者简介
杨定法(1996-),在读硕士研究生,主要从事中药资源开发与利用研究;通信作者:赵声兰,E-maiil:13330431529@163.com。
