摘要
隐球菌性脑膜炎是由隐球菌侵犯脑膜和(或)脑实质所导致的中枢神经系统感染, 以严重的颅内压增高、脑实质损害为特征, 起病隐匿。这种机会性感染常见于人类免疫缺陷病毒(HIV)感染者、器官移植受者或其他免疫抑制情况, 也见于少部分免疫功能正常人群。在全球HIV感染逐年减少的背景下, 隐球菌性脑膜炎仍然有较高的发病率, 且病死率居高不下。文中重点对隐球菌性脑膜炎的易患人群、临床表现、影像学特点、诊断方法及治疗方案进行介绍。
Cryptococcal meningitis is a central nervous system infection caused by cryptococcal invasion of meninges and(or)brain parenchyma.It is characterized by severe intracranial hypertension and brain parenchyma damage.This opportunistic infection commonly occurs among HIV infected individuals,organ transplant recipients,and other immunosuppressive situations,and otherwise immunologically normal hosts.The global burden of human immunodeficiency virus/acquired immunodeficiency syndrome has declined over the years,but cryptococcal meningitis still has a high morbidity and mortality.The risk groups,clinical presentation,imaging characteristics,diagnostic criteria and therapeutic issues were reviewed in this article.
作者
王芙蓉
梁奇明
Wang Furong;Liang Qiming(Department of Neurology,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2022年第8期886-892,共7页
Chinese Journal of Neurology
关键词
隐球菌
脑膜炎
HIV
抗真菌药
颅内压
Cryptococcus
Meningitis
HIV
Antifungal agents
Intracranial pressure
作者简介
通信作者:王芙蓉,Email:wangfurong.china@163.com。
