摘要
目的探讨氨磺必利联合奥氮平治疗精神分裂症患者的疗效及对患者糖脂代谢和睡眠质量的影响。方法71例精神分裂症患者,随机分为对照组(35例)和观察组(36例)。对照组患者口服奥氮平治疗,观察组患者在对照组基础上增加氨磺必利治疗。比较两组患者治疗前后糖脂代谢指标(总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹血糖),治疗前后匹兹堡睡眠质量指数量表(PSQI)评分。结果治疗后,观察组患者的总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹血糖分别为(5.22±0.98)、(1.75±0.36)、(3.86±0.38)、(0.95±0.34)、(6.21±1.12)mmol/L,与对照组的(5.15±0.95)、(1.68±0.41)、(3.79±0.35)、(0.89±0.32)、(6.15±1.08)mmol/L比较,差异均无统计学意义(P>0.05)。治疗后,两组患者的总胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹血糖水平均显著高于治疗前,而高密度脂蛋白胆固醇水平均显著低于治疗前,差异均有统计学意义(P<0.05)。治疗后,两组患者的PSQI评分均显著低于治疗前,且观察组患者的PSQI评分(9.26±4.25)分显著低于对照组的(12.03±3.98)分,差异均有统计学意义(P<0.05)。结论氨磺必利联合奥氮平治疗精神分裂症患者可有效提升临床效果,且与奥氮平单药治疗比较,未明显增加糖脂代谢紊乱风险。
Objective To discuss the efficacy of amisulpride combined with olanzapine in patients with schizophrenia,and its influence on glucose and lipid metabolism and sleep quality of patients.Methods A total of 71 patients with schizophrenia were randomly divided into control group(35 cases)and observation group(36 cases).Patients in the control group were treated with oral administration of olanzapine,and patients in the observation group were additionally treated with amisulpride on the basis of the control group.The glucose and lipid metabolism indexes(total cholesterol,triglyceride,low-density lipoprotein cholesterol,highdensity lipoprotein cholesterol,fasting blood glucose),and Pittsburgh sleep quality index(PSQI)score before and after treatment were compared between the two groups.Results After treatment,the total cholesterol,triglyceride,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol and fasting blood glucose of the observation group were(5.22±0.98),(1.75±0.36),(3.86±0.38),(0.95±0.34),and(6.21±1.12)mmol/L,and there was no statistically significant difference compared with(5.15±0.95),(1.68±0.41),(3.79±0.35),(0.89±0.32),and(6.15±1.08)mmol/L of the control group(P>0.05).After treatment,the total cholesterol,triglyceride,low-density lipoprotein cholesterol,and fasting blood glucose in the two groups were significantly higher than those before treatment in this group,while the high-density lipoprotein cholesterol was significantly lower than that before treatment in this group,and the differences were statistically significant(P<0.05).After treatment,the PSQI scores of the two groups were significantly lower than those of this group before treatment,and the PSQI score(9.26±4.25)points of the observation group was significantly lower than(12.03±3.98)points of the control group.All the differences were statistically significant(P<0.05).Conclusion The combination therapy of amisulpride and olanzapine can effectively improve the clinical effect,and does not significantly increase the risk of glucose and lipid metabolism disorders compared with olanzapine alone.
作者
李新雪
LI Xin-xue(Anshan Mental Health Center,Anshan 114000,China)
出处
《中国现代药物应用》
2022年第14期160-162,共3页
Chinese Journal of Modern Drug Application
关键词
氨磺必利
奥氮平
精神分裂症
糖脂代谢
睡眠质量
Amisulpride
Olanzapine
Schizophrenia
Glucose and lipid metabolism
Sleep quality
