摘要
目的 探讨奥氮平合并小剂量阿立哌唑治疗精神分裂症的效果和阿立哌唑对奥氮平引起体质量增加及血糖、血脂障碍的影响.方法 选择2017年1月至2018年5月肇庆市第三人民医院收治的100例精神分裂症患者为研究对象,将其随机分为研究组和对照组,每组50例.对照组单一使用奥氮平治疗,剂量为15 mg/d;研究组在对照组治疗基础上加用小剂量阿立哌唑,10 mg/d,早餐后顿服.治疗时间为24周,于入组时及治疗后4、12、24周进行随访.比较两组患者体质量、体质指数、糖脂代谢指标(空腹血糖、三酰甘油、高密度脂蛋白、低密度脂蛋白、总胆固醇)、阳性和阴性综合征量表(PANSS)总分及治疗中不良反应发生情况.结果 研究组患者体质量和体质指数呈递减趋势,而对照组患者体质量和体质指数呈递增趋势,差异有统计学意义(P<0.05).治疗后24周,研究组患者糖脂代谢指标与入组时比较差异未见统计学意义(P>0.05);而对照组空腹血糖、三酰甘油、低密度脂蛋白及总胆固醇均较入组时有所增加,差异有统计学意义(P<0.05).治疗后24周,两组PANSS总分均较入组时降低(P<0.05),但组间比较差异未见统计学意义(P>0.05).两组患者治疗过程中均未发生严重不良事件.结论 小剂量阿立哌唑联合奥氮平治疗精神分裂症疗效确切,安全性高,同时对于奥氮平引起体质量增加及血糖、血脂代谢障碍具有预防治疗作用.
Objective To investigate the efficacy of olanzapine combined with low-dose aripiprazole on patients with schizophrenia,and the effect of aripiprazole on weight gain,blood sugar and lipid disorders induced by olanzapine.Methods One hundred patients with schizophrenia admitted to the Third People's Hospital of Zhaoqing from January 2017 to May 2018 were randomly divided into study group and control group with 50 cases in each group.Patients in control group were treated with olanzapine at a dose of 15mg/d,while patients in study group were treated with aripiprazole at a low dose of 10 mg/d on the basis of treatment for control group.The duration of treatment was 24 weeks.Follow-up was conducted at the time of admission and 4,12 and 24 weeks after treatment.The body mass,body mass index,glycolipid metabolic indexes(fasting blood sugar,triglyceride,high density lipoprotein,low density lipoprotein,total cholesterol),total score of positive and negative syndrome scale(PANSS)and the occurrence of adverse reactions during treatment were compared between the two groups.Results Thebody mass and body mass index of study group showed a decreasing trend,while that of control group showed an increasing trend,and the differences between the two groups were statistically significant(P<0.05).Compared with the preoperative indexes,the glycolipid metabolism had no significant difference 24 weeks after treatment in study group(P>0.05),however,fasting blood glucose,triglyceride,low density lipoprotein and total cholesterol in control group increased 24 weeks after treatment(P<0.05).The total PANSS scores 24 weeks after treatment were significantly lower than those at the time of admission in the two groups(P<0.05),but there was no significant difference between the two groups(P>0.05).There were no serious adverse events during treatment in the both groups.Conclusions Low-dose aripiprazole combined with olanzapine is effective and safe in the treatment of schizophrenia.It also has preventive and therapeutic effects on weight gain,blood sugar and lipid metabolism disorder caused by olanzapine.
作者
何思强
郑育喜
卢建国
陈海珠
梁其生
He Siqiang;Zheng Yuxi;Lu Jianguo;Chen Haizhu;Liang Qisheng(Department of Laboratory,the Third People’s Hospital of Zhaoqing,Zhaoqing 526060,China)
出处
《中国实用医刊》
2019年第19期110-113,共4页
Chinese Journal of Practical Medicine
基金
肇庆市科技创新项目(201704030722).
关键词
奥氮平
阿立哌唑
体质量
血糖
血脂
Olanzapine
Aripiprazole
Body mass
Blood sugar
Blood lipid
作者简介
通信作者:何思强,Email:sq618102@163.com
