摘要
Zwitterions have aroused much interest to endow implantable medical devices with anti-fouling and anti-thrombosis performance,due to their ability to form a hydrated layer that can provide a good barrier against protein and cell adhesion. Herein,tyramine modified sulfobetaine-derived sodium hyaluronan(HST) hydrogel coating was fabricated, in which hyaluronan(HA)was used as polysaccharide skeleton to graft zwitterionic sulfobetaine, and tyramine was introduced as crosslinker to construct both the network of hydrogel and a strong covalent bond between coating and substrate. Hydrogel coating was prepared by spin coating or painting HST prepolymer solution under ultraviolet light irradiation. The obtained HST hydrogel coating shows good stability. Moreover, in addition to its outstanding anti-fouling performance and good biocompatibility, it can effectively prevent thrombosis in blood circulation ex vivo. This work offers a universal strategy to prepare a high-performance anti-fouling and antithrombosis coating, which is expected to promote the development of functional coatings for biomedical materials.
基金
supported by the National Key Research and Development Program of China (Grant No. 2018YFC1105500)
the National Natural Science Foundation of China (Grant Nos. U20A20261,31870948,31971250,and 52073205)
the Natural Science Foundation of Tianjin (Grant Nos. 20JCYBJC00660 and 21JCYBJC00560)。
作者简介
Corresponding author:YAO FangLian,email:yaofanglian@tju.edu.cn;Corresponding author:ZHANG Hong,email:zhanghong@tju.edu.cn;Corresponding author:LI JunJie,email:li41308@tju.edu.cn。
