摘要
A lack of biological activity hinders the application of synthetic hydrogels in tissue engineering and regenerative medicine.However,the use of glycopolypeptides in hydrogel synthesis may provide the materials with the desired biological activities.Herein,we prepared three in situ-forming hydrogels from various phenol-functionalized glycopolypeptides.The gelation time,mechanical properties,degradation properties,and biocompatibility of the hydrogels were assessed.Gelation time ranged from 11 to 380s,depending on the concentration of horseradish peroxidase.The galactose-modified polypeptide hydrogel showed the highest storage modulus with an obvious stress relaxation phenomenon.The prepared hydrogels exhibited good degradation properties and compatibility to cells and tissues.Furthermore,the rate of immune cell accumulation around the mannosemodified polypeptide hydrogel was the fastest among the hydrogels.
基金
supported by the National Natural Science Foundation of China(Grant Nos.21574127
51622307
51520105004
51833010 and51773199)
the Youth Innovation Promotion Association
CAS。
作者简介
Corresponding author:LI Gao,email:ligao@ciac.ac.cn;Corresponding author:HE ChaoLiang,email:clhe@ciac.ac.cn。
