摘要
N6-methyladenosine(m6A)modification is the most widespread and conserved internal mRNA modification in mammalian cells.It greatly affects genetic regulation by enhancing the involvement of diverse cellular enzymes and thus,plays a significant role in basic life processes.Numerous studies on m6A modification identified FTO as a crucial demethylase that participates in various biological processes.Not only does FTO play a pivotal role in obesity-related conditions,but it also influences the occurrence,development,and prognosis of several cancers,such as acute myeloid leukemia,breast cancer,liver cancer,and lung cancer.Moreover,FTO also shows a close association with immunity and viral infections.This article summarized the molecular mechanism of FTO in tumorigenesis and tumor progression.
出处
《BIOCELL》
SCIE
2022年第11期2387-2397,共11页
生物细胞（英文）
基金
This study was supported by the Natural Science Foundation of Guangdong Provincial(2019A1515011911)
the Research Program of Shenzhen Innovation Council(JCYJ20200109140208058)
the Sanming Project of Medicine in Shenzhen(SZSM202111012)
the Oral and Maxillofacial Surgery Team,Professor Yu Guangyan,Stomatological Hospital Peking University,Guangdong Provincial High-Level Clinical Key Specialty(Shenzhen Matching Construction Fund)(Grant No.SZGSP008).
作者简介
HONGYU YANG,Yang-Hongyu192@hotmail.com。
