摘要
目的探讨自拟补肺饮治疗慢性阻塞性肺疾病稳定期(肺肾气虚证)的临床疗效。方法选取符合纳入标准的慢阻肺稳定期患者60例,以随机数字表法分2组,每组30例,对照组采用沙美特罗替卡松粉吸入治疗,治疗组采用沙美特罗替卡松粉吸入+自拟补肺饮内服治疗,疗程12周。对比两组临床疗效、治疗前后慢阻肺患者自我评估测试问卷(CAT)、改良的医学研究委员会呼吸困难量表(mMRC)评分、肺功能及免疫功能。结果治疗组治疗总有效率(93.33%)高于对照组(83.33%),差异有统计学意义(P<0.05);治疗组和对照组CAT、mMRC评分较治疗前下降(P<0.05),且治疗组优于对照组(P<0.05);两组第1秒用力呼气量预计值与第1秒用力呼气量占用力肺活量的比值高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05);治疗组血清免疫球蛋白IgM和IgG升高水平高于对照组,差异具有统计学意义(P<0.05)。结论自拟补肺饮治疗慢阻肺稳定期患者临床疗效显著,可有效改善患者的呼吸功能,应积极应用于临床。
Objective To observe the clinical efficacy of self-made Bufei Decoction on chronic obstructive pulmonary disease(COPD)in stable phase(lung-kidney qi deficiency syndrome).Methods Sixty patients with stable COPD were randomly divided into two groups,30 in each group.The control group was treated with salmeterol-fluticasone,and the treatment group was given Bufei Decoction on the basis of salmeterol-fluticasone for 12 weeks.The COPD Assessment Test(CAT)score,Modified Medical Research Council(mMRC)dyspnea score,lung ventilation function and immunologic function in the two groups were compared before and after treatment.Results The total effective rates were 93.33%in the treatment group and 83.33%in the control group,and the difference was statistically significant(P<0.05).The CAT score and mMRC score were lower than those before treatment in the two groups(P<0.05),with better changes in the treatment group than the control group.There was an uptrend in FEV1%predicted(FEV1:forced expiratory volume in one second)and FEV1/FVC ratio(FVC:forced vital capacity)in the two groups after treatment,which were higher in the treatment group(P<0.05).The immunoglobulin M(Ig M)and immunoglobulin G(IgG)levels in the treatment group were higher than those in the control group(P<0.05).Conclusion The self-made Bufei Decoction could improve the clinical symptoms and respiratory function,with distinct efficacy,which should be applied to clinical practice.
作者
李文凭
汪蔚青
于宏梅
赵德强
LI Wenping;WANG Weiqing;YU Hongmei;ZHAO Deqiang(Putuo District Central Hospital of Shanghai,Shanghai 200063,China)
出处
《基层中医药》
2022年第5期41-46,共6页
Basic Traditional Chinese Medicine
关键词
自拟补肺饮
慢性阻塞性肺疾病
肺肾气虚
临床研究
Bufei Decoction
chronic obstructive pulmonary disease
lung-kidney qi deficiency syndrome
clinical study
作者简介
通讯作者:李文凭,E-mail:wendylee1900@126.com。
