摘要
目的分析降钙素原、N-末端脑钠肽前体检测对重症呼吸衰竭预后的评估价值。方法60例重症呼吸衰竭患者,根据预后不同分为存活组(45例)和死亡组(15例)。采集所有患者的血液标本,应用免疫荧光定量法检测降钙素原,免疫化学发光法检测N-末端脑钠肽前体。对比两组降钙素原、N-末端脑钠肽前体水平。结果存活组患者降钙素原、N-末端脑钠肽前体水平分别为(1.87±0.57)μg/L、(2354.87±841.83)pg/ml,显著低于死亡组的(8.23±3.98)μg/L、(4257.68±914.65)pg/ml,差异具有统计学意义(P<0.05)。结论降钙素原和N-末端脑钠肽前体是重要的生化标志物,其对重症呼吸衰竭的预后评估有重要临床价值。
Objective To analyze the value of procalcitonin combined with N-terminal pro-brain natriuretic peptide precursor in evaluating the prognosis of patients with severe respiratory failure.Methods A total of 60 patients with severe respiratory failure were divided into survival group(45 cases)and death group(15 cases)according to different prognosis.Blood samples were collected from all patients,and immunofluorescence quantitative method was used to detect procalcitonin,and immunochemiluminescence method was used to detect N-terminal pro-brain natriuretic peptide precursor.The levels of procalcitonin and N-terminal pro-brain natriuretic peptide precursor were compared between the two groups.Results The levels of procalcitonin and N-terminal pro-brain natriuretic peptide precursor in the survival group were(1.87±0.57)μg/L and(2354.87±841.83)pg/ml,which were significantly lower than(8.23±3.98)μg/L and(4257.68±914.65)pg/ml in the death group,and the differences were statistically significant(P<0.05).Conclusion Procalcitonin and N-terminal pro-brain natriuretic peptide precursor are important biochemical markers,which have important clinical value in prognosis evaluation of severe respiratory failure.
作者
翟进诚
郑建明
闵家星
ZHAI Jin-cheng;ZHENG Jian-ming;MIN Jia-xing(Fengxin County People's Hospital,Yichun 330700,China)
出处
《中国现代药物应用》
2022年第12期88-90,共3页
Chinese Journal of Modern Drug Application
关键词
降钙素原
N-末端脑钠肽前体
重症呼吸衰竭
预后
Procalcitonin
N-terminal pro-brain natriuretic peptide precursor
Severe respiratory failure
Prognosis
