摘要
肠屏障由机械屏障、化学屏障、免疫屏障及微生物屏障共同组成,是机体抵御微生物入侵的重要防线.肠屏障各组分在生理情况下相互协调,维持肠道内外环境的稳态.创伤失血性休克时,肠道灌注不足、肠缺血再灌注损伤等诸多因素作用下肠屏障功能容易发生障碍,可发生细菌易位,内毒素入血等,引发肠源性感染和多器官功能障碍,甚至导致死亡.当前,国内外关于创伤失血性休克肠屏障功能损伤机制和防治措施有较多理念上的更新和技术进展.本文拟结合本团队前期研究,对此领域做一文献综述,以期为临床上预防和治疗创伤后肠功能障碍相关疾病提供系统全面的理论体系.
The intestinal barrier is composed of mechanical barrier,chemical barrier,immune barrier,and microbial barrier,which has an important role in defense against microbial invasion.The components of intestinal barrier coordinate with each other under physiological conditions to maintain the homeostasis of intestinal internal and external environment.In traumatic hemorrhagic shock,intestinal barrier function is prone to be impaired by intestinal hypoperfusion,intestinal ischemia-reperfusion injury,and many other factors.Bacterial translocation and endotoxin entry into the blood may occur,leading to enterogenic infection,multiple organ dysfunction,and even death.At present,there are many conceptual updates and technical progress on the mechanisms,prevention,and treatment of intestinal barrier function injury in traumatic hemorrhagic shock both at home and abroad.This paper intends to make a literature review in this field based on the previous research of our team,in order to provide a systematic and comprehensive theoretical system for the clinical prevention and treatment of post-traumatic intestinal dysfunction related diseases.
作者
陈方
储诚南
丁威威
Fang Chen;Cheng-Nan Chu;Wei-Wei Ding(Research Institute of General Surgery,Jinling Hospital,School of Medicine,Southeast University,Nanjing 210002,Jiangsu Province,China;Research Institute of General Surgery,Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,Jiangsu Province,China)
出处
《世界华人消化杂志》
CAS
2022年第12期547-554,共8页
World Chinese Journal of Digestology
基金
创伤、烧伤与复合伤国家重点实验室开放课题资助,No.SKLKF202103.
关键词
创伤
失血性休克
肠屏障
Trauma
Hemorrhagic shock
Intestinal barrier
作者简介
陈方,硕士研究生,研究方向为肠屏障功能研究;通讯作者:丁威威,博士,教授,210002,江苏省南京市中山东路305号,东南大学医学院第二临床学院(东部战区总医院)普通外科研究所.dingwei_nju@hotmail.com。
