摘要
目的:探讨非酒精性脂肪性肝病(NAFLD)严重程度与氧化应激、SAA、CRP和脑动脉硬化的相关性。方法:选取消化内科诊断为NAFLD的患者227例,其中轻度NAFLD患者116例,中度NAFLD患者74例,重度NAFLD患者37例,并选取健康对照组49例,对病史和血样进行采集,并检测不同程度患者的氧化应激标记物和炎症相关因子。结果:NAFLD患者的BMI、高血压病、糖尿病、高脂血症、TG、TC、LDL-C、FBG、HbA1c、GGT、SBP、DBP均高于健康对照组(P<0.05),中度NAFLD患者的BMI、TG、HDL-C、ALT、AST、GGT水平高于轻度NAFLD(P<0.05),重度NAFLD高于中度NAFLD,三组之间具有显著性差异(P<0.05);NAFLD患者的MDA、NO的水平较健康对照组显著升高(P<0.05),SOD、CAT、GPx、GSH、GST水平较健康对照组明显降低(P<0.05),轻度、中度、重度NAFLD患者的MDA、NO的水平显著升高,具有显著性(P<0.05),SOD、CAT、GPx、GSH、GST水平明显降低,差异具有统计学意义(P<0.05);NAFLD患者SAA、CRP、INF-a、IL-6、MCP-1和PAI-1水平较健康对照组显著升高(P<0.05),轻度、中度、重度NAFLD患者SAA、CRP、INF-a、IL-6、MCP-1和PAI-1水平明显升高,差异具有统计学意义(P<0.05);健康对照组、轻度、中度、重度NAFLD患者脑动脉硬化的发生率分别为0%、0%、9.46%和24.32%,在多变量logistic回归分析中发现,不同程度NAFLD患者的BMI、TG、TC、HDL-C、ALT、AST、MDA、NO、SOD、GPx、GSH、SAA、CRP、INF-a、IL-6、MCP-1和PAI-1是脑动脉硬化发生的危险因素(P<0.05),不同程度NAFLD脂肪肝患者的氧化应激GGT、CAT、GST与脑动脉硬化无相关性(P>0.05)。结论:不同程度NAFLD患者的炎症因子INF-a、IL-6、MCP-1和PAI-1是脑动脉硬化发生的危险因素,具有相关性,不同程度NAFLD患者的氧化应激MDA、NO、SOD、GPx、GSH活性与脑动脉硬化也具有一定的相关性。
Objective:To explore the relationship between the severity of fatty liver in patients with fatty liver and oxidative stress, SAA, CRP and cerebral arteriosclerosis.Methods:Selected 227 patients with non-alcoholic fatty liver(NAFLD) diagnosed in the Gastroenterology Department, 116 patients with mild NAFLD, 74 patients with moderate NAFLD, 37 patients with severe NAFLD, and 49 columns of healthy controls were selected, and the medical history and Blood samples were collected and tested for oxidative stress markers and inflammation-related factors in patients with different degrees. Results:The levels of BMI, TG, HDL-C, ALT, AST, and GGT of patients with moderate NAFLD were higher than those of mild NAFLD(P<0.05), and severe NAFLD was higher than moderate NAFLD. There was a significant difference between the three groups(P<0.05).The levels of MDA and NO in patients with mild, moderate, and severe NAFLD were significantly increased(P<0.05), and the levels of SOD, CAT, GPx, GSH, and GST were significantly reduced, and the difference was statistically significant(P<0.05);SAA, CRP, INF-α, IL-6, MCP-1 and PAI-1 levels in patients with mild, moderate, and severe NAFLD were significantly increased,and the difference was statistically significant( P < 0. 05);The incidence of cerebral arteriosclerosis in patients with moderate,moderate,and severe NAFLD were 0%,9. 46%,and 24. 32%,respectively;in the multivariate logistic regression analysis,it was found that BMI,TG,TC,HDL-C,ALT in patients with different degrees of fatty liver,AST,MDA,NO,SOD,GPx,GSH,SAA,CRP,INF-α,IL-6,MCP-1 and PAI-1 were risk factors for cerebral arteriosclerosis and were related( P < 0. 05),The oxidative stress GGT,CAT,GST of patients with different degrees of fatty liver has no correlation with cerebral arteriosclerosis( P > 0. 05). Conclusion: Inflammatory factors of INF-α,IL-6,MCP-1 and PAI-1 in patients with different degrees of fatty liver are risk factors for the occurrence of cerebral arteriosclerosis and are related. Oxidative stress in patients with different degrees of fatty liver is MDA,NO,SOD. The activities of GPx,GSH and cerebral arteriosclerosis also have a certain correlation.
作者
杨跃青
张燕
寇少杰
董璐
YANG Yue-qing;ZHANG Yan;KOU Shao-jie(Department of Hepatology and Hematology,Shanxi Provincial Hospital of Traditional Chinese Medicine(Xi'an Shanxi,710082)China;不详)
出处
《中西医结合肝病杂志》
CAS
2022年第6期520-524,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
陕西省中医药科研项目资助(No.LCPT010)。
作者简介
通讯作者:张燕,E-mail:asqxo2@163.com。
