摘要
目的:观察加味小青龙汤治疗风痰恋肺型上气道咳嗽综合征(upper airway cough syndrome,UACS)的临床疗效及其对中医证候积分的影响。方法:选择80例风痰恋肺型UACS患者作为研究对象,以抽签法分为两组,对照组(n=40)采用常规西医治疗,观察组(n=40)在对照组治疗基础上给予加味小青龙汤。比较两组患者临床疗效、中医证候积分、咳嗽视觉模拟量表(visual analogue scale,VAS)评分、症状消失时间、免疫功能、炎症因子、不良反应发生率。结果:观察组有效率为97.50%,明显高于对照组的80.00%(P<0.05)。观察组治疗后主症(咳嗽、咽痒、咳痰)证候积分、次症(鼻塞、鼻后滴流感、频繁清嗓、咽喉有异物感)证候积分明显低于同期对照组(P<0.05)。观察组咳嗽,咽部、鼻部症状消失时间均明显少于对照组(P<0.05)。观察组日间咳嗽症状评分、夜间咳嗽症状评分及咳嗽VAS评分均明显低于对照组(P<0.05)。观察组治疗后CD_(3)^(+)、CD_(4)^(+)水平高于同期对照组,CD_(8)^(+)低于同期对照组(P<0.05)。观察组治疗后白细胞介素-6、肿瘤坏死因子-α、超敏-C反应蛋白水平低于同期对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加味小青龙汤治疗风痰恋肺型UACS疗效显著,能够有效改善临床症状及咳嗽程度,调节机体免疫功能,减轻炎症反应。
Objective:To observe the clinical efficacy of Modified Xiaoqinglong Decoction in treatment of upper airway cough syndrome(UACS)of Wind-Phlegm in Lung type and its effect on TCM syndrome scores.Methods:80 cases of UACS patients with Wind-Phlegm Persisting in Lung type were selected as the research objects and divided into two groups by lottery method.The control group(n=40)was treated with conventional western medicine,and the observation group(n=40)was given Modified Xiaoqinglong Decoction treatment based on the treatment of the control group.The clinical efficacy,TCM syndrome score,visual analogue scale(VAS)score of coughs,symptom disappearance time,immune function,inflammatory factors,and incidence of adverse reactions were compared between the two groups.Results:The effective rate of the observation group was 97.50%,which was significantly higher than that of the control group,80.00%(P<0.05).After treatment,the main symptoms(cough,sore throat,expectoration)syndrome scores and secondary symptoms(nasal congestion,post-nasal drip,frequent throat clearing,foreign body sensation in the throat)syndrome scores in the observation group were significantly lower than those in the control group at the same period(P<0.05).And the disappearance time of cough,pharyngeal and nasal symptoms in the observation group was significantly shorter than that in the control group(P<0.05).The daytime cough symptom score,nighttime cough symptom score,and cough VAS score in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of CD_(3)^(+)and CD_(4)^(+)in the observation group were higher than those in the control group at the same period,and CD_(8)^(+)was lower than that in the control group at the same period(P<0.05).And the levels of interleukin-6,tumor necrosis factor-α,and high-sensitivity-C-reactive protein in the observation group were lower than those in the control group at the same period(P<0.05).Also,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Xiaoqinglong Decoction has a significant curative effect in treatment of UACS with Wind-Phlegm in Lung type.It can effectively improve the clinical symptoms and cough degree,regulate the immune function of the body,and reduce the inflammatory response.
作者
杨献丽
YANG Xianli(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2022年第8期1742-1748,共7页
Acta Chinese Medicine
基金
河南省科技攻关计划项目(202102310491,172102310288)。
关键词
上气道咳嗽综合征
小青龙汤
风痰恋肺证
中医证候积分
免疫功能
炎症因子
upper airway cough syndrome
Xiaoqinglong Decoction
Wind-Phlegm in Lung syndrome
TCM syndrome score
immune function
inflammatory factor
作者简介
杨献丽(1979-),女,河南驻马店人,医学硕士,主治医师,研究方向:中医药防治儿科疾病。
